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Valamina: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Valamina - General Information

Valamina is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. Valamina exists as small alkaline deliquescent crystals with a saline taste.
Valamina was introduced to medicine as a solvent for uric acid. When taken into the body the drug is partly oxidized and partly eliminated unchanged. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful.
Valamina was first introduced as an anthelmintic in 1953. A large number of piperazine compounds have anthelmintic action. Their mode of action is generally by paralysing parasites, which allows the host body to easily remove or expel the invading organism.

 

Pharmacology of Valamina

Valamina is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Valamina hydrate and piperazine citrate are the main anthelminthic piperazines.

 

Valamina for patients

 

Valamina Interactions

Phenothiazines - Taking piperazine and a phenothiazine together may increase the risk of convulsions (seizures).
Pyrantel (e.g., Antiminth) - Taking piperazine and pyrantel together may decrease the effects of piperazine.

 

Valamina Contraindications

Patients with hypersensitivity to piperazine salts or a history of renal function impairment should avoid this medication

 

Additional information about Valamina

Valamina Indication: Used as alternative treatment for ascariasis caused by Ascaris lumbricoides (roundworm) and enterobiasis (oxyuriasis) caused by Enterobius vermicularis (pinworm). It is also used to treat partial intestinal obstruction by the common roundworm, a condition primarily occurring in children. Mechanism Of Action: Valamina is a GABA receptor agonist. Piperzine binds directly and selectively to muscle membrane GABA receptors, presumably causing hyperpolarization of nerve endings, resulting in flaccid paralysis of the worm. While the worm is paralyzed, it is dislodged from the intestinal lumen and expelled live from the body by normal intestinal peristalsis. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Piperazine Synonyms: fluphenazine dihydrochloride; Glycine anhydride; Hexahydropyrazine; Diethylenediamine; Diethyleneimine; Diketopiperazine; Piperazin [Germany]; Piperazine Citrate; Piperazin; Piperazine hexahydrate; Piperazine hydrate; Prolixin Decanoate Drug Category: Antinematodal Agents; Anthelmintics Drug Type: Small Molecule; Approved Other Brand Names containing Piperazine: Anatensol; Antepan; Antepar; Antiren; Asca-Trol No. 3; Bryrel; Dapotum; Dispermine; Entacyl; Eraverm; Lumbrical; Lyogen; Moditen; Multifuge; Omca; Pacinol; Permitil; Piperazidine; Pipersol; Siqualone; Tasnon; Tensofin; Upixon; Uvilon; Valamina; Vermex; Vermidol; Vermizine; Worm-A-Ton; Worm-away; Wurmirazin; Absorption: Rapidly absorbed from the gastrointestinal tract Toxicity (Overdose): LD50 = 5 g/kg (Human, oral). Symptoms of overdose include muscle fatigue, seizures, and difficulty breathing. Protein Binding: 60-70% Biotransformation: About 25% is metabolized in the liver. Piperazine is nitrosated to form N -mononitrosopiperazine (MNPz) in gastric juice, which is then metabolized to N-nitroso-3-hydroxypyrrolidine (NHPYR). Half Life: Not Available Dosage Forms of Valamina: Solution / drops OralLiquid OralSyrup Oral Chemical IUPAC Name: piperazine Chemical Formula: C4H10N2 Piperazine on Wikipedia: https://en.wikipedia.org/wiki/Piperazine Organisms Affected: Parasitic nematodes and other roundworms