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Uramustine: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Uramustine - General Information

Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. [PubChem]

 

Pharmacology of Uramustine

Uracil Mustard selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Uracil Mustard-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

 

Additional information about Uramustine

Uramustine Indication: Used for its antineoplastic properties. Mechanism Of Action: After activation, it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Uracil mustard Synonyms: Not Available Drug Category: Antineoplastic Agents Drug Type: Small Molecule; Approved Other Brand Names containing Uracil mustard: Aminouracil Mustard; Chlorethaminacil; Demethyldopan; Desmethyldopan; Haemanthamine; Nordopan; Uracil nitrogen mustard; Uracillost; Uracilmostaza; Uramustin; Uramustine; Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: 5% Biotransformation: Not Available Half Life: Not Available Dosage Forms of Uramustine: Not Available Chemical IUPAC Name: 5-[bis(2-chloroethyl)amino]-1H-pyrimidine-2,4-dione Chemical Formula: C8H11Cl2N3O2 Uracil mustard on Wikipedia: https://en.wikipedia.org/wiki/Uracil_mustard Organisms Affected: Humans and other mammals