Unipen

Unipen - General Information

A semi-synthetic antibiotic related to penicillin. [PubChem]

Pharmacology of Unipen

Unipen is a semisynthetic antibiotic substance derived from 6-amino-penicillanic acid. The drugs in this class are highly resistant to inactivation by staphylococcal penicillinase and are active against penicillinase-producing and non penicillinase-producing strains of Staphylococcus aureus. The penicillinase- resistant penicillins are active in vitro against a variety of other bacteria.

Unipen for patients

Unipen Interactions

Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided.

Unipen Contraindications

A history of a hypersensitivity (anaphylactic) reaction to any penicillin is a contraindication.

Additional information about Unipen

Unipen Indication: For the treatment of infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drugs.
Mechanism Of Action: Penicillinase-resistant penicillins exert a bactericidal action against penicillin-susceptible microorganisms during the state of active multiplication. All penicillins inhibit the biosynthesis of the bacterial cell wall.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Nafcillin
Synonyms: Nafcilina [INN-Spanish]; Nafcillin Sodium; Nafcillin sodium salt; Nafcilline [INN-French]; Nafcillinum [INN-Latin]
Drug Category: Anti-Bacterial Agents; Penicillins
Drug Type: Small Molecule; Approved

Other Brand Names containing Nafcillin: Nafcilin-1; Nafcillin sodium for injection; Nallpen; Nallpen In Plastic Container; Naphcillin; Unipen;
Absorption: Not Available
Toxicity (Overdose): Serious toxicity is unlikely following large doses of nafcillin. Acute ingestion of large doses of nafcillin may cause nausea, vomiting, diarrhea and abdominal pain. Acute oliguric renal failure and hematuria may occur following large doses.
Protein Binding: 89.9 ±1.5%
Biotransformation: Hepatic metabolism accounts for less than 30% of the biotransformation of most penicillins.
Half Life: The serum half-life of nafcillin administered by the intravenous route ranged from 33 to 61 minutes as measured in three separate studies.
Dosage Forms of Unipen: Solution Oral
Chemical IUPAC Name: (2S,5R,6R)-6-[(2-ethoxynaphthalene-1-carbonyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Chemical Formula: C21H22N2O5S
Nafcillin on Wikipedia: https://en.wikipedia.org/wiki/Nafcillin
Organisms Affected: Enteric bacteria and other eubacteria