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Tomudex: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Tomudex - General Information

Tomudex (brand name Tomudex®) is a chemotherapy drug manufactured AstraZeneca Company, is an antimetabolite used in chemotherapy. It is an inhibitor of thymidylate synthase.

 

Pharmacology of Tomudex

Tomudex belongs to a group of medicines known as antimetabolites. It is used to treat cancer of the colon and rectum. It may also be used to treat other kinds of cancer, as determined by your doctor. Tomudex blocks an enzyme needed by the cell to live. This interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by raltitrexed, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern.

 

Tomudex for patients

 

Tomudex Interactions

 

Tomudex Contraindications

Raltitrexed should not be used when in the medical problem such as hepatic function impairment, severe Renal function impairment. Avoid using Raltitrexed or consult medical practitioner before taking Raltitrexed when there is problem of Bone marrow depression, Chickenpox, Herpes zoster. Patient should take preaautions if have had previous cytotoxic drug or radiation therapy.

 

Additional information about Tomudex

Tomudex Indication: For the treatment of malignant neoplasm of colon and rectum Mechanism Of Action: Tomudex is an antineoplastic Agents and folic acid antagonists. Tomudex inhibits thymidylate synthase (TS) leading to DNA fragmentation and cell death. It is transported into cells via a reduced folate carrier. Inside the cell Tomudex is extensively polyglutamated, which enhances thymidylate synthase inhibitory power and duration, resulting into increase of antitumor activity. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Raltitrexed Synonyms: ZD1694 Drug Category: Antimetabolites; Antineoplastic Agents; Enzyme Inhibitors; Folic Acid Antagonists Drug Type: Small Molecule; Approved Other Brand Names containing Raltitrexed: Tomudex; Absorption: Not Available Toxicity (Overdose): Side effects include pale skin, troubled breathing, unusual bleeding or bruising, unusual tiredness or weakness, black, tarry stools, chest pain, chills, cough, fever, painful or difficult urination, shortness of breath, sore throat, sores, ulcers, or white spots on lips or in mouth, swollen glands, increase in bowel movements, loose stools, soft stools. Protein Binding: >93% Biotransformation: Raltitrexed is transported into cells via a reduced folate carrier. Inside the cell it is extensively polyglutamated by the enzyme folyl polyglutamate synthetase to polyglutamate forms. Half Life: 198 hours Dosage Forms of Tomudex: Powder, for solution Intravenous Chemical IUPAC Name: (2S)-2-[[5-[methyl-[(2-methyl-4-oxo-1H-quinazolin-6-yl)methyl]amino]thiophene-2-carbonyl]amino]pentanedioic acid Chemical Formula: C21H22N4O6S Raltitrexed on Wikipedia: https://en.wikipedia.org/wiki/Raltitrexed Organisms Affected: Humans and other mammals