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Tagocid: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Tagocid - General Information

Tagocid is a glycopeptide antibiotic. It is a mixture of several compounds, five major (named teicoplanin A2-1 through A2-5) and four minor (named teicoplanin RS-1 through RS-4). All teicoplanins share a same glycopeptide core, termed teicoplanin A3-1, a fused ring structure to which two carbohydrates (mannose and N-acetylglucosamine) are attached. The major and minor components also contain a third carbohydrate moiety, β-D-glucosamine, and differ only by the length and conformation of a side chain attached to it. [Wikipedia]

 

Pharmacology of Tagocid

Tagocid is an antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus and Enterococcus faecalis. It is a glycopeptide antiobiotic extracted from Actinoplanes teichomyceticus, with a similar spectrum of activity to vancomycin. Its mechanism of action is to inhibit bacterial cell wall synthesis. Oral teicoplanin has been demonstrated to be effective in the treatment of pseudomembranous colitis and Clostridium difficile-associated diarrhoea, with comparable efficacy to vancomycin.

 

Additional information about Tagocid

Tagocid Indication: For the treatment of bacterial infections caused by susceptible microorganisms. Mechanism Of Action: Tagocid inhibits peptidoglycan polymerization, resulting in inhibition of bacterial cell wall synthesis and cell death. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Teicoplanin Synonyms: Teichomycin; Teicomycin A2; Teicoplanin; Antibiotic 8327A; Antibiotic MDL 507 Drug Category: Antibacterial Agents; Glycopeptide antibacterials Drug Type: Biotech; Approved Other Brand Names containing Teicoplanin: Targocid; Tagocid; Absorption: Teicoplanin is poorly absorbed after oral administration but is 90% bioavailable when administered intramuscularly. Toxicity (Overdose): Not Available Protein Binding: 90% to 95% Biotransformation: Two metabolites (metabolites 1 and 2; 2 to 3% of total teicoplanin) have been isolated after intravenous administration of radiolabeled teicoplanin. After purification, their structures were found to be new teicoplanin-like molecules, bearing 8-hydroxydecanoic and 9-hydroxydecanoic acyl moieties. This metabolic transformation is likely due to hydroxylation in the omega-2 and omega-1 positions for metabolites 1 and 2, respectively, of the C-10 linear side chain of component A2-3. This might explain the low extent of metabolism of teicoplanin if we consider that only component A2-3 has a linear chain that is susceptible to such oxidation. Half Life: 70-100 hours Dosage Forms of Tagocid: Not Available Chemical IUPAC Name: Not Available Chemical Formula: C88H97Cl2N9O33 Teicoplanin on Wikipedia: https://en.wikipedia.org/wiki/Teicoplanin Organisms Affected: Gram-positive Bacteria