Tacef

Tacef - General Information

Tacef is a third-generation cephalosporin antibiotic. [Wikipedia]

Pharmacology of Tacef

Tacef is a semisynthetic beta-lactam cephalosporin antibiotic with activity similar to that of cefotaxime. It has broad spectrum activity against Gram positive and Gram negative bacteria.

Additional information about Tacef

Tacef Indication: Used to treat female gynecologic and obstetric infections caused by susceptible aerobic (including the gonococcus) and anaerobic bacteria.
Mechanism Of Action: The bactericidal activity of cefmenoxime results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). Tacef is stable in the presence of a variety of b-lactamases, including penicillinases and some cephalosporinases.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Cefmenoxime
Synonyms: Cefmenoxima [INN-Spanish]; Cefmenoxime hydrochloride; Cefmenoximum [INN-Latin]
Drug Category: Anti-Bacterial Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Cefmenoxime: Cefmax; Tacef; Bestcall;
Absorption: Bioavailability is approximately 100% following intramuscular injection.
Toxicity (Overdose): Information on cefmenoxime overdosage in humans is not available. However, with other b-lactam antibiotics, adverse effects following overdosage have included nausea, vomiting, epigastric distress, diarrhea, and convulsions.
Protein Binding: 50-70%
Biotransformation: Not appreciably metabolized.
Half Life: 1 hour
Dosage Forms of Tacef: Powder, for solution Intramuscular
Powder, for solution Intravenous
Chemical IUPAC Name: (6R,7R)-7-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Chemical Formula: C16H17N9O5S3
Cefmenoxime on Wikipedia: https://en.wikipedia.org/wiki/Cefmenoxime
Organisms Affected: Enteric bacteria and other eubacteria