Syntrom

Syntrom - General Information

A coumarin that is used as an anticoagulant. Its actions and uses are similar to those of warfarin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p233)

Pharmacology of Syntrom

Syntrom is a coumarin that is used as an anticoagulant. Its actions and uses are similar to those of warfarin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p233)

Additional information about Syntrom

Syntrom Indication: For the treatment and prevention of thromboembolic diseases.
Mechanism Of Action: Syntrom inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors II, VII, and X) results in decresed prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Acenocoumarol
Synonyms: Nitrowarfarin; Nitrovarfarian; Nitrophenylacetylethyl-4-hydroxycoumarine; Acenocoumarolum [inn-latin]; Nicoumalone; Nicumalon; Acenocoumarin
Drug Category: Anticoagulants; Coumarin and Indandione Derivatives
Drug Type: Small Molecule; Approved

Other Brand Names containing Acenocoumarol: Sintrom; Sinthrome; Syncoumar; Syncumar; Syntrom; Zotil; Sinthrom; Sinkumar; Sincoumar; Neositron; Ascumar;
Absorption: Not Available
Toxicity (Overdose): The onset and severity of the symptoms are dependent on the individual's sensitivity to oral anticoagulants, the severity of the overdosage, and the duration of treatment. Bleeding is the major sign of poisoning with oral anticoagulant drugs. The most frequent symptoms observed are: cutaneous bleeding (80%), haematuria (with renal colic) (52%), haematomas, gastrointestinal bleeding, haematemesis, uterine bleeding, epistaxis, gingival bleeding and bleeding into the joints. Further symptoms include tachycardia, hypotension, peripheral circulatory disorders due to loss of blood, nausea, vomiting, diarrhoea and abdominal pains.
Protein Binding: Not Available
Biotransformation: Hepatic.
Half Life: 8 to 11 hours.
Dosage Forms of Syntrom: Tablet Oral
Tablet Oral
Chemical IUPAC Name: 2-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]chromen-4-one
Chemical Formula: C19H15NO6
Acenocoumarol on Wikipedia: https://en.wikipedia.org/wiki/Acenocoumarol
Organisms Affected: Humans and other mammals