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Sursumid: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Sursumid - General Information

A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)

 

Pharmacology of Sursumid

Sursumid is a substituted benzamide derivative and a selective dopamine D2 antagonist with antipsychotic and antidepressant activity. Other benzamide derivatives include metoclopramide, tiapride, and sultopride.

 

Additional information about Sursumid

Sursumid Indication

Sursumid is indicated for the treatment of schizophrenia.

Mechanism Of Action
In contrast to most other neuroleptics which block both dopamine D1 and D2 receptors, Sursumid is more selective and acts primarily as a dopamine D2 antagonist. Sursumid appears to lack effects on norepinephrine, acetylcholine, serotonin, histamine, or gamma-aminobutyric acid (GABA) receptors.
Generic Name
Sulpiride
Synonyms
Levosulpirida [Inn-Spanish]; Levosulpiride; Levosulpiride [Inn]; Levosulpiridum [Inn-Latin]; Sulpirida [Inn-Spanish]; Sulpiridum [Inn-Latin]; Sulpirid; Sulpyrid
Drug Category
Antidepressants; Antipsychotics
Drug Type
Small Molecule; Approved
Other Brand Names containing Sulpiride
Abilit; Aiglonyl; Alimoral; Calmoflorine; Championyl; Coolspan; Darleton; Desmenat; Dobren; Dogmatil; Dogmatyl; Dolmatil; Dresent; Eclorion; Eglonil; Eglonyl; Enimon; Equilid; Eusulpid; Fardalan; Fidelan; Guastil; Isnamide; Kylistro; Levobren; Levopraid; Lisopiride; Mariastel; Meresa; Miradol; Mirbanil; Misulvan; Neogama; Norestran; Normum; Nufarol; Omiryl; Omperan; Ozoderpin; Psicocen; Pyrikappl; Pyrkappl; Restful; Sernevin; Splotin; Stamonevrol; Sulpitil; Sulpride; Suprium; Sursumid; Synedil; Trilan; Valirem; Zemorcon;
Absorption
Sulpiride is absorbed slowly from the gastrointestinal tract. Its oral bioavailability is only 25 to 35% with marked interindividual differences.
Toxicity (Overdose)
Sulpiride has a relatively low order of acute toxicity. Substantial amounts may cause severe but reversible dystonic crises with torticollis, protrusion of the tongue, and/or trism. In some cases all the classical symptoms typical of severe Parkinson's Disease may be noted; in others, over-sedation/coma may occur.
Half Life
6 to 8 hours
Dosage Forms of Sursumid
Tablet Oral
Chemical IUPAC Name
N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
Chemical Formula
C15H23N3O4S
Organisms Affected
Humans and other mammals