Spheromycin

Spheromycin - General Information

An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Spheromycin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189) [PubChem]

Pharmacology of Spheromycin

Spheromycin is an aminocoumarin antibiotic that was produced by the actinomycete Streptomyces niveus. Spheromycin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. Other antibiotics in the aminocoumarin class include coumermycin A1 and clorobiocin.

Additional information about Spheromycin

Spheromycin Indication: For the treatment of infections due to staphylococci and other susceptible organisms
Mechanism Of Action: Spheromycin is an aminocoumarin. Aminocoumarins are very potent inhibitors of bacterial DNA gyrase and work by targeting the GyrB subunit of the enzyme involved in energy tranduction. Spheromycin as well as the other aminocoumarin antibiotics act as competitive inhibitors of the ATPase reaction catalysed by GyrB.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Novobiocin
Synonyms: Novobiocina [Inn-Spanish]; Novobiocine [Inn-French]; Novobiocinum [Inn-Latin]; NOV; Crystallinic Acid; Antibiotic Pa-93
Drug Category: Anti-Bacterial Agents; Enzyme Inhibitors; Nucleic Acid Synthesis Inhibitors
Drug Type: Small Molecule; Approved

Other Brand Names containing Novobiocin: Albamix; Cardelmycin; Cathocin; Cathomycin; Inamycin; Novo-R; Robiocina; Sirbiocina; Spheromycin; Stilbiocina; Streptonivicin; Albamycin;
Absorption: Oral bioavailability is negligible.
Toxicity (Overdose): Not Available
Protein Binding: 95%
Biotransformation: Not Available
Half Life: 6 hours
Dosage Forms of Spheromycin: Injection, powder, for solution Intravenous
Chemical IUPAC Name: [(3R,4S,5R,6R)-5-hydroxy-6-[2-hydroxy-3-[[4-hydroxy-3-(3-methylbut-2-enyl)benzoyl]amino]-8-methyl-4-oxochromen-7-yl]oxy-3-methoxy-2,2-dimethyloxan-4-yl] carbamate
Chemical Formula: C31H36N2O11
Novobiocin on Wikipedia: https://en.wikipedia.org/wiki/Novobiocin
Organisms Affected: Enteric bacteria and other eubacteria