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Sonebon tofraniln a: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Sonebon tofraniln a - General Information

A benzodiazepine derivative used as an anticonvulsant and hypnotic.

 

Pharmacology of Sonebon tofraniln a

Sonebon tofraniln a is a type of benzodiazepine drug. It is a powerful hypnotic drug which possesses strong sedative, anxiolytic, amnestic, anticonvulsant, and skeletal muscle relaxant properties. Sonebon tofraniln a shortens the time required to fall asleep and lengthens the duration of sleep. It is also useful for the management of myoclonic seizures.

 

Additional information about Sonebon tofraniln a

Sonebon tofraniln a Indication

Used to treat short-term sleeping problems (insomnia), such as difficulty falling asleep, frequent awakenings during the night, and early-morning awakening.

Mechanism Of Action
Sonebon tofraniln a belongs to a group of medicines called benzodiazepines. It acts on benzodiazepine receptors in the brain which are associated with the GABA receptors causing an enhanced binding of GABA (gamma amino butyric acid) to GABAA receptors. GABA is a major inhibitory neurotransmitter in the brain, involved in inducing sleepiness, muscular relaxation and control of anxiety and fits, and slows down the central nervous system. The anticonvulsant properties of nitrazepam and other benzodiazepines may be in part or entirely due to binding to voltage-dependent sodium channels rather than benzodiazepine receptors. Sustained repetitive firing seems to be limited by benzodiazepines effect of slowing recovery of sodium channels from inactivation.
Food Interactions
Avoid alcohol.
Generic Name
Nitrazepam
Synonyms
1, 3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one; 1,3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one; 2,3-Dihydro-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2-on; 7-Nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one; 7-Nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 7-Nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one; N-desmethylnimetazepam; Nitrazepamum [inn-latin]; NTZ
Drug Category
Anti-anxiety Agents; Anticonvulsants; GABA Modulators; Hypnotics and Sedatives
Drug Type
Small Molecule; Approved
Other Brand Names containing Nitrazepam
Apo-nitrazepam tablets BP; Apodorm; Atempol; Benzalin; Calsamin; Calsmin; Cerson; Dormicum; Dormin-5; Dormo-puren; Dumolid; Eatan; Eatan n; Epibenzalin; Epinelbon; Eunoctin; Eunoktin; Gerson; Hipnax; Hipsal; Ibrovek; Imeson; Imesont; Insomin; Ipersed; LA 1 (VAN); Magadon; Megadon; Mitidin; Mogadan; Mogadon; Mogadone; Nelbon; Nelmat; Neozepam; Neuchlonic; Nitrados; Nitravet; Nitrazadon; Nitrazepam-10; Nitrazepam-5; Nitrempax; Nitrenpax; Noctesed; Pacisyn; Paxisyn; Pelson; Persopit; Radedorm; Relact; Remnos; Sandoz nitrazepam; Somitran; Somnased; Somnibel; Somnite; Sonebon; Sonebon tofraniln a; Sonnolin; Surem; Trazenin; Unisomnia; Alodorm;
Absorption
Bioavailability is 53-94% following oral administration.
Toxicity (Overdose)
Nitrazepam is a drug which is very frequently involved in drug intoxication, including overdose. Nitrazepam overdose may result in stereotypical symptoms of benzodiazepine overdose including intoxication, impaired balance, slurred speech. In cases of severe overdose this may progress to a comatose state with the possibility of death.
Half Life
15-38 hours (mean elimination half life 26 hours).
Dosage Forms of Sonebon tofraniln a
Tablet Oral
Chemical IUPAC Name
7-nitro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
Chemical Formula
C15H11N3O3
Organisms Affected
Humans and other mammals