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Siquil: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Siquil - General Information

A phenothiazine used as an antipsychotic agent and as an antiemetic. [PubChem]

 

Pharmacology of Siquil

Siquil is a member of a class of drugs called phenthiazines, which are dopamine D1/D2 receptor antagonists. Phenothiazines are used to treat serious mental and emotional disorders, including schizophrenia and other psychotic disorders. It reduces anxiety, emotional withdrawal, hallucinations, disorganized thoughts, blunted mood, and suspiciousness. Siquil is used particularly to control violent behavior during acute episodes of psychotic disorders. It can also be used to control severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients. Siquil acts on the central nervous system.

 

Additional information about Siquil

Siquil Indication: Used mainly in the management of psychoses. Also used to control nausea and vomiting. Mechanism Of Action: Siquil binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. The mechanism of the anti-emetic effect is due predominantly to blockage of the dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone (CTZ) and vomiting centre. Siquil blocks the neurotransmitter dopamine and the vagus nerve in the gastrointestinal tract. Siquil also binds the muscarinic acetylcholine receptors (M1 and M2) and the tryptamine D receptors (5HT2B). Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Triflupromazine Synonyms: Not Available Drug Category: Antipsychotics; Antiemetics Drug Type: Small Molecule; Approved Other Brand Names containing Triflupromazine: Adazine; Fluopromazine; Psyquil; Siquil; Trifluopromazine; Absorption: Absorption may be erratic and peak plasma concentrations show large interindividual differences. Toxicity (Overdose): Symptoms of overdose include agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, and restlessness. Protein Binding: Very high (90% or more). Biotransformation: Hepatic. Half Life: Not Available Dosage Forms of Siquil: Not Available Chemical IUPAC Name: N,N-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine Chemical Formula: C18H19F3N2S Triflupromazine on Wikipedia: https://en.wikipedia.org/wiki/Triflupromazine Organisms Affected: Humans and other mammals