Silbephylline: Full Drug Profile

Silbephylline - General Information

A theophylline derivative with broncho- and vasodilator properties. It is used in the treatment of asthma, cardiac dyspnea, and bronchitis. [PubChem]

Pharmacology of Silbephylline

Silbephylline, a xanthine derivative, is a bronchodilator used for relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema. Silbephylline is a xanthine derivative with pharmacologic actions similar to theophylline and other members of this class of drugs. Its primary action is that of bronchodilation, but it also exhibits peripheral vasodilatory and other smooth muscle relaxant activity to a lesser degree.

Silbephylline for patients

Silbephylline Interactions

Synergism between xanthine bronchodilators (e.g., theophylline), ephedrine, and other sympathomimetic bronchodilators has been reported. This should be considered whenever these agents are prescribed concomitantly.

Concurrent administration of dyphylline and probenecid, which competes for tubular secretion, has been shown to increase the plasma half-life of dyphylline.

Silbephylline Contraindications

Hypersensitivity to dyphylline or related xanthine compounds.

Additional information about Silbephylline

Silbephylline Indication

For relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema.

Mechanism Of Action

The bronchodilatory action of dyphylline, as with other xanthines, is thought to be mediated through competitive inhibition of phosphodiesterase with a resulting increase in cyclic AMP producing relaxation of bronchial smooth muscle.

Generic Name

Dyphylline

Synonyms

Diprophylline; Dipropylline; Diprophyllin; Diprofilline; Diprofillin; Dihydroxypropyl Theopylin; Dihydroxypropyl Theophylline; DT

Drug Category

Vasodilator Agents; Bronchodilator Agents; Respiratory Smooth Muscle Relaxants; Phosphodiesterase Inhibitors

Drug Type

Small Molecule; Approved

Other Brand Names containing Dyphylline

Afi-Phyllin; Aristophyllin; Asthmolysin; Astrophyllin; Circain; Cor-Theophylline; Coronal; Coronarin; Corphyllin; Droxine; Dyflex; Glyfyllin; Glyphyllin; Glyphylline; Hidroxiteofillina; Hiphyllin; Hyphylline; Iphyllin; Liactemin; Neo-Vasophylline; Neophyl; Neophyllin; Neophylline; Neostenovasan; Neotilina; Neufil; Neutrafil; Neutrafillina; Neutraphyllin; Neutraphylline; Neutroxantina; Propyphyllin; Protheophylline; Purifilin; Silbephyllin; Silbephylline; Solufilin; Solufyllin; Soluphyllin; Synthophylline; Tefilan; Teofen; Theal; Thefylan;

Toxicity (Overdose)

LD₅₀=1954 mg/kg (orally in mice)

Protein Binding

84%

Biotransformation

Hepatic

Half Life

2 hours (range 1.8 - 2.1 hours)

Dosage Forms of Silbephylline

Tablet Oral

Chemical IUPAC Name

7-(2,3-dihydroxypropyl)-1,3-dimethylpurine-2,6-dione

Chemical Formula

C10H14N4O4

Organisms Affected

Humans and other mammals