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Sevinol: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Sevinol - General Information

A phenothiazine used in the treatment of psychoses. Its properties and uses are generally similar to those of chlorpromazine. [PubChem]

 

Pharmacology of Sevinol

Sevinol is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Sevinol has not been shown effective in the management of behaviorial complications in patients with mental retardation.

 

Sevinol for patients

Given the likelihood that some patients exposed chronically to neuroleptics will develop tardive dyskinesia, it is advised that all patients in whom chronic use is contemplated be given, if possible, full information about this risk. The decision to inform patients and/or their guardians must obviously take into account the clinical circumstances and the competency of the patient to understand the information provided.

 

Sevinol Interactions

No information provided.

 

Sevinol Contraindications

Phenothiazines are contraindicated in patients with suspected or established subcortical brain damage, in patients receiving large doses of hypnotics, and in comatose or severely depressed states. The presence of blood dyscrasia or liver damage precludes the use of fluphenazine hydrochloride. Fluphenazine hydrochloride is contraindicated in patients who have shown hypersensitivity to fluphenazine; cross-sensitivity to phenothiazine derivatives may occur.

 

Additional information about Sevinol

Sevinol Indication: For management of manifestations of psychotic disorders. Mechanism Of Action: Sevinol blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. Drug Interactions: Amphetamine Decreased anorexic effect, may increase psychotic symptomsAtomoxetine This CYP2D6 inhibitor could increase the effect and toxicity of atomoxetineBenzphetamine Decreased anorexic effect, may increase psychotic symptomsBromocriptine The phenothiazine decreases the effect of bromocriptineCisapride Increased risk of cardiotoxicity and arrhythmiasDextroamphetamine Decreased anorexic effect, may increase psychotic symptomsDexfenfluramine Decreased anorexic effect, may increase psychotic symptomsDiethylpropion Decreased anorexic effect, may increase psychotic symptomsFenfluramine Decreased anorexic effect, may increase psychotic symptomsGatifloxacin Increased risk of cardiotoxicity and arrhythmiasGrepafloxacin Increased risk of cardiotoxicity and arrhythmiasLevofloxacin Increased risk of cardiotoxicity and arrhythmiasGuanethidine The agent decreases the effect of guanethidineTerfenadine Increased risk of cardiotoxicity and arrhythmiasSparfloxacin Increased risk of cardiotoxicity and arrhythmiasMazindol Decreased anorexic effect, may increase psychotic symptomsMethamphetamine Decreased anorexic effect, may increase psychotic symptomsMetrizamide Increased risk of convulsionsPhendimetrazine Decreased anorexic effect, may increase psychotic symptomsPhenmetrazine Decreased anorexic effect, may increase psychotic symptomsPhentermine Decreased anorexic effect, may increase psychotic symptomsPhenylpropanolamine Decreased anorexic effect, may increase psychotic symptoms Food Interactions: Avoid alcohol.Take with food to reduce irritation. Generic Name: Fluphenazine Synonyms: Triflumethazine; Fluphenazine Hcl; Fluphenazine Decanoate; Fluorphenazine; Fluorophenazine; Fluorfenazine Drug Category: Antipsychotics; Phenothiazines Drug Type: Small Molecule; Approved Other Brand Names containing Fluphenazine: Apo-Fluphenazine; Elinol; Modecate; Moditen Enanthate; Moditen Hcl; Permitil Concentrate; Prolixin; Prolixin Concentrate; Prolixin Enanthate; Prolixine; Sevinol; Siqualine; Siqualon; Vespazine; Yespazine; Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Sevinol: Tablet OralElixir OralLiquid Intramuscular Chemical IUPAC Name: 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol Chemical Formula: C22H26F3N3OS Fluphenazine on Wikipedia: https://en.wikipedia.org/wiki/Fluphenazine Organisms Affected: Humans and other mammals