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SecreFlo: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

SecreFlo - General Information

This drug is the synthetic form of natural secretin. It is prepared using solid phase peptide synthesis. SecreFlo is a peptide hormone produced in the S cells of the duodenum. Its main effect is to regulate the pH of the small intestine’s contents through the control of gastric acid secretion and buffering with bicarbonate. It was the first hormone to be discovered.

 

Pharmacology of SecreFlo

Used in the diagnosis of pancreatic dysfunction or gastrinoma (stomach cancer), secretin is a hormone produced in the S cells of the duodenum in response to low local pH. It stimulates the secretion of bicarbonate from bicarbonate producing organs(liver, pancreas, Brunner's glands) when the pH drops below a set value. This helps neutralize the gastric acid entering the duodenum from the stomach. It also inhibits acid secretion from the stomach by reducing gastrin release from the G cells of the stomach.

 

SecreFlo for patients

 

SecreFlo Interactions

Drug/Laboratory Test Interaction: The concomitant use of anticholinergic agents may make patients hyporesponsive, i.e. may produce a false positive result.

 

SecreFlo Contraindications

Patients suffering from acute pancreatitis should not receive SecreFlo™ until the acute episode has subsided.

 

Additional information about SecreFlo

SecreFlo Indication: For diagnosis of pancreatic exocrine dysfunction and gastrinoma Mechanism Of Action: SecreFlo binds to the secretin receptor found on the lining of S cells in the duodenum and G cells in the stomach. Binding leads to the secrection of bicarbonate or the reduction of the secretion of gastrin. Properly functioning organs (duodenum, pancreas and stomach) should be responsive to this hormone Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Secretin Synonyms: Secremax, SecreFlo Drug Category: Diagnostic Agents Drug Type: Biotech; Approved; Investigational Other Brand Names containing Secretin: Secremax, SecreFlo (Repligen Corp); SecreFlo; Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of SecreFlo: Injection, powder, lyophilized, for solution Intravenous Chemical IUPAC Name: Not Available Chemical Formula: C130H219N43O42 Secretin on Wikipedia: https://en.wikipedia.org/wiki/Secretin Organisms Affected: Humans and other mammals