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Santyl (Advance Biofactures Corp): Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Santyl (Advance Biofactures Corp) - General Information

The enzyme collagenase is derived from fermentation of Clostridium histolyticum

 

Pharmacology of Santyl (Advance Biofactures Corp)

Used in the treatment of skin ulcers and sever burns, collagenase is able to digest collagen in necrotic tissue at physiological pH. Santyl (Advance Biofactures Corp) thus contributes towards the formation of granulation tissue and subsequent epithelization of dermal ulcers and severely burned areas.

 

Santyl (Advance Biofactures Corp) for patients

 

Santyl (Advance Biofactures Corp) Interactions

 

Santyl (Advance Biofactures Corp) Contraindications

Collagenase Santyl® Ointment is contraindicated in patients who have shown local or systemic hypersensitivity to collagenase.

 

Additional information about Santyl (Advance Biofactures Corp)

Santyl (Advance Biofactures Corp) Indication: For treatment of chronic dermal ulcers and severe skin burns Mechanism Of Action: Santyl (Advance Biofactures Corp) is a protease that is specific to collagen. The triple helical region of interstitial collagens is highly resistant to most cell proteinases. However, during remodeling of the connective tissue in such processes as wound healing and metastasis, collagen becomes susceptible to cleavage by collagenases. Santyl (Advance Biofactures Corp) cleaves all 3 alpha helical chains of native Types I, II and III collagens at a single locus by hydrolyzing the peptide bond following the Gly residue of the sequence: Gly 775-(Ile or Leu) 776-(Ala or Leu) 777 located approximately three-fourths of the chain length from each N-terminus Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Collagenase Synonyms: Not Available Drug Category: Anti-Ulcer Agents; Topical Drug Type: Biotech; Approved Other Brand Names containing Collagenase: Santyl (Advance Biofactures Corp); Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Santyl (Advance Biofactures Corp): Ointment Topical Chemical IUPAC Name: Clostridium histolyticum collagenase Chemical Formula: C5028H7666N1300O1564S21 Collagenase on Wikipedia: https://en.wikipedia.org/wiki/Collagenase Organisms Affected: Humans and other mammals