Rondomycin: Full Drug Profile
Rondomycin - General Information
A broad-spectrum semisynthetic antibiotic related to tetracycline but excreted more slowly and maintaining effective blood levels for a more extended period. [PubChem]
Pharmacology of Rondomycin
Rondomycin, a macrolide antibiotic similar to erythromycin and azithromycin, is effective against Mycobacterium avium complex (MAC) and is used for the treatment of Helicobacter pylori-associated peptic ulcer disease, community-acquired pneumonia, sinusitis, and chronic bronchitis. Rondomycin is also used to treat respiratory tract, sexually transmitted, otitis media, and AIDS-related infections.
Additional information about Rondomycin
Rondomycin Indication: For the treatment of acute bacterial exacerbations of chronic bronchitis Mechanism Of Action: Rondomycin is first metabolized to 14-OH Rondomycin. Like other macrolides, it then binds to the 50 S subunit of the 70 S ribosome of the bacteria, blocking RNA-mediated bacterial protein synthesis. Rondomycin also inhibits the hepatic microsomal CYP3A4 isoenzyme and P-glycoprotein, an energy-dependent drug efflux pump. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Methacycline Synonyms: Metacycline; Methacyclin Drug Category: Anti-Bacterial Agents Drug Type: Small Molecule; Approved Other Brand Names containing Methacycline: Rondomycin; Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Rondomycin: Not Available Chemical IUPAC Name: (2Z,4S,4aR,5S,5aR,12aS)-2-(amino-hydroxymethylidene)-4-dimethylamino-5,10,11,12a-tetrahydroxy-6-methylidene-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione Chemical Formula: C22H22N2O8 Methacycline on Wikipedia: https://en.wikipedia.org/wiki/Methacycline Organisms Affected: Enteric bacteria and other eubacteria