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Rogitine: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Rogitine - General Information

A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of raynaud disease and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease. [PubChem]

 

Pharmacology of Rogitine

Rogitine is indicated for the control of episodes of hypertension and sweating that occur with a disease called pheochromocytoma. If tachycardia is excessive, it may be necessary to use a beta-blocking agent concomitantly. Rogitine is a long-acting, adrenergic, alpha-receptor blocking agent which can produce and maintain "chemical sympathectomy" by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system. Rogitine works by blocking alpha receptors in certain parts of the body. Alpha receptors are present in the muscle that lines the walls of blood vessels. When the receptors are blocked by Rogitine, the muscle relaxes and the blood vessels widen. This widening of the blood vessels results in a lowering of blood pressure.

 

Rogitine for patients

 

Rogitine Interactions

Diagnosis of pheochromocytoma - phentolamine blocking test.

The test is most reliable in detecting pheochromocytoma in patients with sustained hypertension and least reliable in those with paroxysmal hypertension. False-positive tests may occur in patients with hypertension without pheochromocytoma.

 

Rogitine Contraindications

Myocardial infarction, history of myocardial infarction, coronary insufficiency, angina, or other evidence suggestive of coronary artery disease; hypersensitivity to phentolamine or related compounds.

 

Additional information about Rogitine

Rogitine Indication: For the prevention or treatment of dermal necrosis and sloughing following intravenous administration or extravasation of norepinephrine. Also for the prevention or control of hypertensive episodes that may occur in a patient with pheochromocytoma as a result of stress or manipulation during preoperative preparation and surgical excision. Mechanism Of Action: Rogitine produces its therapeutic actions by blocking alpha receptors, leading to a muscle relaxation and a widening of the blood vessels. This widening of the blood vessels results in a lowering of blood pressure. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Phentolamine Synonyms: Not Available Drug Category: Antihypertensive Agents; Sympatholytics Drug Type: Small Molecule; Approved Other Brand Names containing Phentolamine: Phenotolamine; Phentalamine; Phentolamine Mesilate; Phentolamine Mesylate; Phentolamine Mesylate [USAN]; Phentolamine Methanesulfonate; Phentolamine Methanesulphonate; Phentolamine, Methyl Sulfonate; Regitin; Regitin Methanesulphonate; Regitine; Regitine Mesylate; Regitine Methanesulfonate; Regitipe; Rogitine; Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Not Available Half Life: 19 minutes Dosage Forms of Rogitine: Solution IntravenousTablet, extended release Oral Chemical IUPAC Name: 3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphenyl)amino]phenol Chemical Formula: C17H19N3O Phentolamine on Wikipedia: https://en.wikipedia.org/wiki/Phentolamine Organisms Affected: Humans and other mammals