Roferon A (Hoffmann-La Roche Inc): Full Drug Profile

Roferon A (Hoffmann-La Roche Inc) - General Information

Recombinant protein of 165 residues, prepared from E. coli, has K23 as part of the native sequence

Pharmacology of Roferon A (Hoffmann-La Roche Inc)

Upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens. This enhances the activation of CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the macrophage a better target for CTL-mediated killing. Interferon alpha also induce the synthesis of several key antiviral mediators, including 2'-5' oligoadenylate synthetase (2'-5' A synthetase) and protein kinase R.

Additional information about Roferon A (Hoffmann-La Roche Inc)

Roferon A (Hoffmann-La Roche Inc) Indication

For treatment of chronic hepatitis C, hairy cell leukemia, AIDS-related Kaposi's sarcoma, and chronic myelogenous leukemia

Mechanism Of Action

Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription)which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon alpha binds less stably to type I interferon receptors than interferon beta.

Drug Interactions

Aminophylline Interferon increases the effect and toxicity of theophylline

Food Interactions

Avoid alcohol.

Generic Name

Interferon alfa-2a

Synonyms

Interferon alpha-2 precursor; Interferon alpha-A; LeIF A

Drug Category

Antineoplastic Agents; Antiviral Agents

Drug Type

Biotech; Approved

Other Brand Names containing Interferon alfa-2a

Roferon A (Hoffmann-La Roche Inc);

Half Life

1.2 hours (mammalian reticulocytes, in vitro)

Dosage Forms of Roferon A (Hoffmann-La Roche Inc)

Injection, solution Subcutaneous

Chemical IUPAC Name

Human interferon alpha 2a

Chemical Formula

C860H1353N227O255S9

Organisms Affected

Humans and other mammals