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Retrone: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Retrone - General Information

A synthetic progestational hormone with no androgenic or estrogenic properties. Unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit ovulation. [PubChem]

 

Pharmacology of Retrone

Retrone is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus. At therapeutic levels, dydrogesterone has no contraceptive effect as it does not inhibit or interfere with ovulation or the corpus luteum. Furthermore, dydrogesterone is non-androgenic, non-estrogenic, non-corticoid, non-anabolic and is not excreted as pregnanediol. Retrone helps to regulate the healthy growth and normal shedding of the uterus lining. Therefore, it may be useful in the treatment of menstrual disorders such as absent, irregular or painful menstrual periods, infertility, premenstrual syndrome and endometriosis.

 

Retrone for patients

 

Retrone Interactions

 

Retrone Contraindications

Contraindicated in patients with undiagnosed vaginal bleeding nor to those with a history of thromboembolic disorders.

 

Additional information about Retrone

Retrone Indication: Used to treat irregular duration of cycles and irregular occurrence and duration of periods caused by progesterone deficiency. Also used to prevent natural abortion in patients who have a history of habitual abortions. Mechanism Of Action: Retrone is a progestogen that works by regulating the healthy growth and normal shedding of the womb lining by acting on progesterone receptors in the uterus. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Dydrogesterone Synonyms: 10alpha-Isopregnenone; Didrogesterone [DCIT]; Dydrogesterona [INN-Spanish]; Dydrogesteronum [INN-Latin]; Hydrogesterone; Hydrogestrone; Isopregnenone Drug Category: Pregnadien derivatives; Progesterones Drug Type: Small Molecule; Approved Other Brand Names containing Dydrogesterone: Diphaston; Dufaston; Duphaston; Duvaron; Gestatron; Gynorest; Prodel; Retrone; Terolut; Absorption: Rapidly absorbed in the gastrointestinal tract with a bioavailability of 28%. Toxicity (Overdose): No serious or unexpected toxicity has been observed with dydrogesterone. In acute toxicity studies, the LD50 doses in rats exceeded 4,640mg/kg for the oral route. Protein Binding: Not Available Biotransformation: Metabolism is complete to a 20-dihydrodydrogesterone (DHD) metabolite. Half Life: Dydrogesterone: 5-7 hours, 20-dihydrodydrogesterone (DHD) metabolite: 14-17 hours Dosage Forms of Retrone: Tablet Oral Chemical IUPAC Name: (8S,9R,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one Chemical Formula: C21H28O2 Dydrogesterone on Wikipedia: https://en.wikipedia.org/wiki/Dydrogesterone Organisms Affected: Humans and other mammals