Retin-A
Retin-A - General Information
An important regulator of gene expression during growth and development, and in neoplasms. Tretinoin, also known as retinoic acid and derived from maternal vitamin A, is essential for normal growth; and embryonic development. An excess of tretinoin can be teratogenic. It is used in the treatment of psoriasis; acne vulgaris; and several other skin diseases. It has also been approved for use in promyelocytic leukemia (leukemia, promyelocytic, acute). [PubChem]
Pharmacology of Retin-A
Retin-A (9-cis-retinoic acid) is a naturally-occurring endogenous retinoid indicated for topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma. Retin-A inhibits the growth of Kaposi's sarcoma (KS) cells in vitro.
Retin-A for patients
Retin-A Interactions
Patients who are applying Panretin® gel should not concurrently use products that contain DEET (N, N-diethyl-m-toluamide), a common component of insect repellent products. Animal toxicology studies showed increased DEET toxicity when DEET was included as proof of the formulation. Although there was no clinical evidence in the vehicle-controlled studies of drug interactions with systemic antiretroviral agents, including protease inhibitors, macrolide antibiotics, and azole antifungals, the effect of Panretin® gel on the steady-state concentrations of these drugs is not known. No drug interaction data are available on concomitant administration of Panretin® gel and systemic anti-KS agents.
Retin-A Contraindications
Panretin® gel is contraindicated in patients with a known hypersensitivity to retinoids or to any of the ingredients of the product.
Additional information about Retin-A
Retin-A Indication: For topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma.
Mechanism Of Action: Retin-A binds to and activates all known intracellular retinoid receptor subtypes (RARa, RARb, RARg, RXRa, RXRb and RXRg). Once activated these receptors function as transcription factors that regulate the expression of genes that control the process of cellular differentiation and proliferation in both normal and neoplastic cells.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Alitretinoin
Synonyms: Retinoic Acid; ALRT-1057; BAL4079
Drug Category: Antineoplastic Agents
Drug Type: Small Molecule; Approved; Investigational
Other Brand Names containing Alitretinoin: Panretin; Panretin Gel; Panretyn; Panrexin; Renova; Retin-A; Retin-A Micro; Vesanoid;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Retin-A: Liquid Topical
Gel Topical
Cream Topical
Capsule Oral
Chemical IUPAC Name: (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenoic acid
Chemical Formula: C20H28O2
Alitretinoin on Wikipedia: https://en.wikipedia.org/wiki/Alitretinoin
Organisms Affected: Humans and other mammals
