Repronex
Repronex - General Information
Mixture of luteinizing hormone and follicle stimulating hormone extracted from the urine of postmeonopausal women. Composed of LH with 2 subunits, alpha = 92 residues, beta = 121 residues and FSH with 2 subunits, alpha = 92 residues, beta=111 residues
Pharmacology of Repronex
Used to treat female infertility, Repronex stimulates late follicular maturation and resumption of oocyte meiosis, and initiates rupture of the pre-ovulatory ovarian follicle. Repronex bind to the LH/hCG/FSH receptor of the granulosa and theca cells of the ovary to effect these changes in the absence of an endogenous LH surge.
Repronex for patients
Prior to therapy with Repronex®, patients should be informed of the duration of treatment and the monitoring of their condition that will be required. Possible adverse reactions and the risk of multiple births should also be discussed.
Repronex Interactions
Repronex Contraindications
Repronex is contraindicated in women who have:
1. A high FSH level indicating primary ovarian failure.
2. Uncontrolled thyroid and adrenal dysfunction.
3. An organic intracranial lesion such as a pituitary tumor.
4. The presence of any cause of infertility other than anovulation unless they are candidates for in vitro- fertilization.
5. Abnormal bleeding of undetermined origin.
6. Ovarian cysts or enlargement not due to polycystic ovary syndrome.
7. Prior hypersensitivity to menotropins.
8. Repronex is not indicated in women who are pregnant. There are limited human data on the effects of menotropins when administered during pregnancy.
Additional information about Repronex
Repronex Indication: For treatment of female infertility
Mechanism Of Action: Repronex bind to the Follicle stimulating hormone receptor which results in ovulation in the absence of sufficient endogenous Luteinizing hormone.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Menotropins
Synonyms: LH-B; LSH- beta; LSH-B; Luteinizing hormone beta subunit; Lutropin beta chain precursor
Drug Category: Fertility Agents
Drug Type: Biotech; Approved
Other Brand Names containing Menotropins: Repronex;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Repronex: Powder, for solution Subcutaneous
Powder, for solution Intramuscular
Chemical IUPAC Name: Not Available
Chemical Formula: C1014H1609N287O294S27
Menotropins on Wikipedia: https://en.wikipedia.org/wiki/Menotropins
Organisms Affected: Humans and other mammals