Regulin: Full Drug Profile

Regulin - General Information

A guanidinium antihypertensive agent that acts by blocking adrenergic transmission.

Pharmacology of Regulin

Regulin is a guanidinium antihypertensive agent that acts by blocking adrenergic transmission. The precise mode of action is not clear. Although bethanidine may produce adverse effects, they are beneficial in severe hypertension and produce fewer side effects than guanethidine.

Regulin for patients

Caution in cardiovascular disease and in history of peptic ulceration.

Regulin Interactions

Regulin Contraindications

• Phaeochromocytoma
• Phaeochromocytoma, malignant
• Heart failure
• Adverse reaction to phenoxybenzamine
• Adverse reaction to phentolamine mesilate
• Adverse reaction to trimetaphan camsilate
• Adverse reaction to diazoxide
• Adverse reaction to hydralazine
• Adverse reaction to other antihypertensives
• Adverse reaction to betanidine

Additional information about Regulin

Regulin Indication

For the treatment of hypertension.

Mechanism Of Action

Regulin, a guanidine derivative, is a peripherally acting antiadrenergic agent. Regulin effectively decreases blood pressure by suppressing renin secretion or interfering with function of the sympathetic nervous system.

Generic Name

Bethanidine

Synonyms

Betanidin; Betanidine; Bethanidine sulfate

Drug Category

Adrenergic Agents; Antihypertensive Agents; Sympatholytics

Drug Type

Small Molecule; Approved

Other Brand Names containing Bethanidine

Esbatal; Regulin; Tenathan;

Absorption

Absorbed rapidly in the gastrointestinal tract following oral administration.

Half Life

9 hours (range 7 to 11 hours)

Dosage Forms of Regulin

Tablet Oral

Chemical IUPAC Name

(2S)-1-[(2E)-2-[(2S)-2,6-dicarboxy-2,3-dihydro-1H-pyridin-4-ylidene]ethylidene]-5,6-dihydroxy-2,3-dihydroindol-1-ium-2-carboxylate

Chemical Formula

C18H16N2O8

Organisms Affected

Humans and other mammals