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Raplon: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Raplon - General Information

Raplon is a piperazinyl androstane derivative which is a non-depolarizing neuromuscular blocking agent.

 

Pharmacology of Raplon

Raplon is a nondepolarizing neuromuscular blocking agent. Neuromuscular blocking agents produce skeletal muscle paralysis by blocking neural transmission at the myoneural junction. The paralysis is selective initially and usually appears in the following muscles consecutively: levator muscles of eyelids, muscles of mastication, limb muscles, abdominal muscles, muscles of the glottis, and finally, the intercostal muscles and the diaphragm. Neuromuscular blocking agents have no clinically significant effect on consciousness or the pain threshold.

 

Additional information about Raplon

Raplon Indication: Used as a muscle relaxant during anesthesia and surgical procedures. Mechanism Of Action: Nondepolarizing neuromuscular blocking agents inhibit neuromuscular transmission by competing with acetylcholine for the cholinergic receptors of the motor end plate, thereby reducing the response of the end plate to acetylcholine. This type of neuromuscular block is usually antagonized by anticholinesterase agents. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Pipecuronium Synonyms: Pipecurium; Pipecuronium bromide Drug Category: Neuromuscular Nondepolarizing Agents Drug Type: Small Molecule; Approved Other Brand Names containing Pipecuronium: Raplon; Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Not Available Half Life: Distribution Normal renal function: 6.22 (range, 1.34 to 10.66) minutes. Renal function impairment: 4.33 (range, 1.69 to 6.17) minutes. Elimination Normal renal function: 1.7 (range, 0.9 to 2.7) hours. The elimination half-life is not altered by hypothermia and bypass. Renal function impairment: 4 (range, 2 to 8.2) hours. [PharmGKB] Dosage Forms of Raplon: Solution Intravenous Chemical IUPAC Name: [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3-acetyloxy-2,16-bis(4,4-dimethylpiperazin-4-ium-1-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate Chemical Formula: C35H62N4O4+2 Pipecuronium on Wikipedia: https://en.wikipedia.org/wiki/Pipecuronium Organisms Affected: Humans and other mammals