Prolixine
Prolixine - General Information
A phenothiazine used in the treatment of psychoses. Its properties and uses are generally similar to those of chlorpromazine. [PubChem]
Pharmacology of Prolixine
Prolixine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Prolixine has not been shown effective in the management of behaviorial complications in patients with mental retardation.
Prolixine for patients
Given the likelihood that some patients exposed chronically to neuroleptics will develop tardive dyskinesia, it is advised that all patients in whom chronic use is contemplated be given, if possible, full information about this risk. The decision to inform patients and/or their guardians must obviously take into account the clinical circumstances and the competency of the patient to understand the information provided.
Prolixine Interactions
No information provided.
Prolixine Contraindications
Phenothiazines are contraindicated in patients with suspected or established subcortical brain damage, in patients receiving large doses of hypnotics, and in comatose or severely depressed states. The presence of blood dyscrasia or liver damage precludes the use of fluphenazine hydrochloride. Fluphenazine hydrochloride is contraindicated in patients who have shown hypersensitivity to fluphenazine; cross-sensitivity to phenothiazine derivatives may occur.
Additional information about Prolixine
Prolixine Indication: For management of manifestations of psychotic disorders.
Mechanism Of Action: Prolixine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
Drug Interactions: Amphetamine Decreased anorexic effect, may increase psychotic symptoms
Atomoxetine This CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Benzphetamine Decreased anorexic effect, may increase psychotic symptoms
Bromocriptine The phenothiazine decreases the effect of bromocriptine
Cisapride Increased risk of cardiotoxicity and arrhythmias
Dextroamphetamine Decreased anorexic effect, may increase psychotic symptoms
Dexfenfluramine Decreased anorexic effect, may increase psychotic symptoms
Diethylpropion Decreased anorexic effect, may increase psychotic symptoms
Fenfluramine Decreased anorexic effect, may increase psychotic symptoms
Gatifloxacin Increased risk of cardiotoxicity and arrhythmias
Grepafloxacin Increased risk of cardiotoxicity and arrhythmias
Levofloxacin Increased risk of cardiotoxicity and arrhythmias
Guanethidine The agent decreases the effect of guanethidine
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Sparfloxacin Increased risk of cardiotoxicity and arrhythmias
Mazindol Decreased anorexic effect, may increase psychotic symptoms
Methamphetamine Decreased anorexic effect, may increase psychotic symptoms
Metrizamide Increased risk of convulsions
Phendimetrazine Decreased anorexic effect, may increase psychotic symptoms
Phenmetrazine Decreased anorexic effect, may increase psychotic symptoms
Phentermine Decreased anorexic effect, may increase psychotic symptoms
Phenylpropanolamine Decreased anorexic effect, may increase psychotic symptoms
Food Interactions: Avoid alcohol.
Take with food to reduce irritation.
Generic Name: Fluphenazine
Synonyms: Triflumethazine; Fluphenazine Hcl; Fluphenazine Decanoate; Fluorphenazine; Fluorophenazine; Fluorfenazine
Drug Category: Antipsychotics; Phenothiazines
Drug Type: Small Molecule; Approved
Other Brand Names containing Fluphenazine: Apo-Fluphenazine; Elinol; Modecate; Moditen Enanthate; Moditen Hcl; Permitil Concentrate; Prolixin; Prolixin Concentrate; Prolixin Enanthate; Prolixine; Sevinol; Siqualine; Siqualon; Vespazine; Yespazine;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Prolixine: Tablet Oral
Elixir Oral
Liquid Intramuscular
Chemical IUPAC Name: 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol
Chemical Formula: C22H26F3N3OS
Fluphenazine on Wikipedia: https://en.wikipedia.org/wiki/Fluphenazine
Organisms Affected: Humans and other mammals
