Proketazine: Full Drug Profile

Proketazine - General Information

Proketazine is an antipsychotic drug, used in hospitalized patients in the management of chronic schizophrenic psychoses.

Pharmacology of Proketazine

Proketazine is a phenothiazine antipsychotic agent with a piperazine side-chain.

Additional information about Proketazine

Proketazine Indication

Used in the treatment of acute or chronic schizophrenic reactions in hospitalized patients.

Mechanism Of Action

A yellow, powdered, phenothiazine antipsychotic agent used in the treatment of acute or chronic schizophrenia. The term "phenothiazines" is used to describe the largest of the five main classes of neuroleptic antipsychotic drugs. These drugs have antipsychotic and, often, antiemetic properties, although they may also cause severe side effects such as akathisia, tardive dyskinesia and extrapyramidal symptoms. Proketazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.

Generic Name

Carphenazine

Synonyms

Carfenazine; Carphenazin

Drug Category

Antipsychotics

Drug Type

Small Molecule; Approved

Other Brand Names containing Carphenazine

Procethazine; Proketazin; Proketazine;

Chemical IUPAC Name

1-[10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazin-2-yl]propan-1-one

Chemical Formula

C24H31N3O2S

Organisms Affected

Humans and other mammals