Priscoline: Full Drug Profile
Priscoline - General Information
A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Priscoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn. [PubChem]
Pharmacology of Priscoline
Priscoline is a pulmonary vasodilator indicated used to decrease pulmonary vascular resistance (PVR) in persistent pulmonary hypertension of the newborn (PPHN).
Additional information about Priscoline
Priscoline Indication: For the treatment of pulmonary artery anomalies Mechanism Of Action: Vasodilation by means of a direct effect on peripheral vascular smooth muscle and indirect effects produced, in part, by release of endogenous histamine; tolazoline has moderate alpha-adrenergic blocking activity and has histamine agonist activity. Priscoline usually reduces pulmonary arterial pressure and vascular resistance. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Tolazoline Synonyms: Not Available Drug Category: Vasodilator Agents; Antihypertensive Agents Drug Type: Small Molecule; Approved Other Brand Names containing Tolazoline: Artonil; Benzazoline; Benzidazol; Benzolin; Benzylimidazoline; Dilatol Asi; Divascol; Imidalin; Imidaline; Kasimid; Lambril; Olitensol; Peripherine; Phenylmethylimidazoline; Prefaxil; Priscol; Priscoline; Tolazolin; Vasimid; Vasodil; Vasodilatan; Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Priscoline: Not Available Chemical IUPAC Name: 2-(phenylmethyl)-4,5-dihydro-1H-imidazole Chemical Formula: C10H12N2 Tolazoline on Wikipedia: https://en.wikipedia.org/wiki/Tolazoline Organisms Affected: Humans and other mammals