Priscoline

Priscoline - General Information

A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Priscoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn. [PubChem]

Pharmacology of Priscoline

Priscoline is a pulmonary vasodilator indicated used to decrease pulmonary vascular resistance (PVR) in persistent pulmonary hypertension of the newborn (PPHN).

Additional information about Priscoline

Priscoline Indication: For the treatment of pulmonary artery anomalies
Mechanism Of Action: Vasodilation by means of a direct effect on peripheral vascular smooth muscle and indirect effects produced, in part, by release of endogenous histamine; tolazoline has moderate alpha-adrenergic blocking activity and has histamine agonist activity. Priscoline usually reduces pulmonary arterial pressure and vascular resistance.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Tolazoline
Synonyms: Not Available
Drug Category: Vasodilator Agents; Antihypertensive Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Tolazoline: Artonil; Benzazoline; Benzidazol; Benzolin; Benzylimidazoline; Dilatol Asi; Divascol; Imidalin; Imidaline; Kasimid; Lambril; Olitensol; Peripherine; Phenylmethylimidazoline; Prefaxil; Priscol; Priscoline; Tolazolin; Vasimid; Vasodil; Vasodilatan;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Priscoline: Not Available
Chemical IUPAC Name: 2-(phenylmethyl)-4,5-dihydro-1H-imidazole
Chemical Formula: C10H12N2
Tolazoline on Wikipedia: https://en.wikipedia.org/wiki/Tolazoline
Organisms Affected: Humans and other mammals