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Poly-RX: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Poly-RX - General Information

Polymyxin B sulfate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, N. gonorrhea and N. menigitidis, are resistant. It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa.

 

Pharmacology of Poly-RX

Polymyxin B sulfate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, N. gonorrhea and N. menigitidis, are resistant.

 

Poly-RX for patients

 

Poly-RX Interactions

No information provided.

 

Poly-RX Contraindications

This drug is contraindicated in persons with a prior history of hypersensitivity reactions to the polymyxins.

 

Additional information about Poly-RX

Poly-RX Indication: For treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa. Mechanism Of Action: Polymyxin B sulfate has a bactericidal action against almost all gram-negative bacilli except the Proteus group. Polymyxin B sulfate binds to and interferes with the permeability of the bacterial cytoplasmic membrane. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Polymyxin B Sulfate Synonyms: Polymixin B sulfate; Polymyxin B sulfate salt; Polymyxin B sulphate Drug Category: Anti-Bacterial Agents Drug Type: Small Molecule; Approved Other Brand Names containing Polymyxin B Sulfate: Aerosporin; Poly-RX; Absorption: Not absorbed from the normal alimentary tract. Toxicity (Overdose): Overdose can cause stomach pains, vomiting, and diarrhea. Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Poly-RX: Powder, for solution OphthalmicPowder, for solution IntrathecalInjection, solution IntramuscularInjection, solution Intravenous drip Chemical IUPAC Name: N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide; sulfuric acid Chemical Formula: C56H100N16O17S Polymyxin B Sulfate on Wikipedia: https://en.wikipedia.org/wiki/Polymyxin_B Organisms Affected: Enteric bacteria and other eubacteria