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Phenuron: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Phenuron - General Information

Phenuron is used to control certain seizures in the treatment of epilepsy. This medicine acts on the central nervous system (CNS) to reduce the number and severity of seizures.

 

Pharmacology of Phenuron

Phenuron is a ureal anticonvulsant indicated for control of severe epilepsy, particularly mixed forms of complex partial (psychomotor or temporal lobe) seizures, refractory to other anticonvulsants. Phenuron elevates the threshold for minimal electroshock convulsions and abolishes the tonic phase of maximal electroshock seizures. It also prevents or modifies seizures induced by pentylenetetrazol or other convulsants.

 

Additional information about Phenuron

Phenuron Indication: Used to control certain seizures in the treatment of epilepsy. Mechanism Of Action: Phenuron binds to and blocks neuronal sodium channels or voltage sensitive calcium channels. This blocks or suppresses neuronal depolarization and hypersynchronization. Hypersynchronization is what often causes seizures. Drug Interactions: Not Available Food Interactions: May be taken with food if stomach upset occurs. Generic Name: Phenacemide Synonyms: Carbamide phenylacetate; PA; Phenacetylcarbamide; Phenacetylurea; Phenylacetylurea; Phenylacetyluree Drug Category: Anticonvulsants Drug Type: Small Molecule; Approved Other Brand Names containing Phenacemide: Acetylureum; Carbanmide; Cetylureum; Comitiadone; Eferon; Efron; Epheron; Epiclase; Felurea; Fenacemid; Fenacemide; Fenacetamide; Fenacetil-Karbamide; Fenilep; Fenised; Fenostenyl; Fenural; Fenurea; Fenurone; Fenylacetylmocovina; Fenytan; Neophedan; Neophenal; Phacetur; Phenacalum; Phenacereum; Phenacetur; Phenarone; Phenicarb; Phenuron; Phenurone; Phenutal; Phenyrit; Phetylureum; Absorption: Almost completely absorbed. Toxicity (Overdose): Oral, mouse: LD50 = 987 mg/kg; Oral, rabbit: LD50 = 2500 mg/kg; Oral, rat: LD50 = 1600 mg/kg Protein Binding: Not Available Biotransformation: Metabolized in the liver by hepatic microsomal enzymes, where it is inactivated by p-hydroxylation. Half Life: 22-25 hours. Dosage Forms of Phenuron: Tablet Oral Chemical IUPAC Name: N-carbamoyl-2-phenylacetamide Chemical Formula: C9H10N2O2 Phenacemide on Wikipedia: https://en.wikipedia.org/wiki/Phenacemide Organisms Affected: Humans and other mammals