Pevaryl
Pevaryl - General Information
A broad spectrum antimycotic with some action against Gram positive bacteria. It is used topically in dermatomycoses also orally and parenterally. [PubChem]
Pharmacology of Pevaryl
Pevaryl is an antifungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex). Pevaryl prevents fungal organisms from producing vital substances required for growth and function. This medication is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections.
Pevaryl for patients
Pevaryl Interactions
No information provided.
Pevaryl Contraindications
SPECTAZOLE Cream is contraindicated in individuals who have shown hypersensitivity to any of its ingredients.
Additional information about Pevaryl
Pevaryl Indication: For topical application in the treatment of tinea pedis, tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Microsporum canis, Microsporum audouini, Microsporum gypseum, and Epidermophyton floccosum, in the treatment of cutaneous candidiasis, and in the treatment of tinea versicolor.
Mechanism Of Action: Pevaryl interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Pevaryl may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Econazole
Synonyms: Not Available
Drug Category: Antifungal Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Econazole: Econazole Nitrate; Ecostatin; Ecostatin Vaginal Ovules; Ecostatin cream; Gyno-Pevaryl; Gyno-Pevaryl 150; Ifenec; Palavale; Pevaryl; Spectazole; Spectazole cream;
Absorption: After topical application to the skin of normal subjects, systemic absorption of econazole nitrate is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes.
Toxicity (Overdose): Overdosage of econazole in humans has not been reported to date. In mice, rats guinea pigs and dogs, the oral LD 50 values were found to be 462, 668, 272, and > 160 mg/kg, respectively.
Protein Binding: Not Available
Biotransformation: Hepatic.
Half Life: Not Available
Dosage Forms of Pevaryl: Suppository Intravaginal
Chemical IUPAC Name: 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole
Chemical Formula: C18H15Cl3N2O
Econazole on Wikipedia: https://en.wikipedia.org/wiki/Econazole
Organisms Affected: Yeast and other fungi
