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Pevaryl: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Pevaryl - General Information

A broad spectrum antimycotic with some action against Gram positive bacteria. It is used topically in dermatomycoses also orally and parenterally. [PubChem]

 

Pharmacology of Pevaryl

Pevaryl is an antifungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex). Pevaryl prevents fungal organisms from producing vital substances required for growth and function. This medication is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections.

 

Pevaryl for patients

 

Pevaryl Interactions

No information provided.

 

Pevaryl Contraindications

SPECTAZOLE Cream is contraindicated in individuals who have shown hypersensitivity to any of its ingredients.

 

Additional information about Pevaryl

Pevaryl Indication: For topical application in the treatment of tinea pedis, tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Microsporum canis, Microsporum audouini, Microsporum gypseum, and Epidermophyton floccosum, in the treatment of cutaneous candidiasis, and in the treatment of tinea versicolor. Mechanism Of Action: Pevaryl interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Pevaryl may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Econazole Synonyms: Not Available Drug Category: Antifungal Agents Drug Type: Small Molecule; Approved Other Brand Names containing Econazole: Econazole Nitrate; Ecostatin; Ecostatin Vaginal Ovules; Ecostatin cream; Gyno-Pevaryl; Gyno-Pevaryl 150; Ifenec; Palavale; Pevaryl; Spectazole; Spectazole cream; Absorption: After topical application to the skin of normal subjects, systemic absorption of econazole nitrate is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes. Toxicity (Overdose): Overdosage of econazole in humans has not been reported to date. In mice, rats guinea pigs and dogs, the oral LD 50 values were found to be 462, 668, 272, and > 160 mg/kg, respectively. Protein Binding: Not Available Biotransformation: Hepatic. Half Life: Not Available Dosage Forms of Pevaryl: Suppository Intravaginal Chemical IUPAC Name: 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole Chemical Formula: C18H15Cl3N2O Econazole on Wikipedia: https://en.wikipedia.org/wiki/Econazole Organisms Affected: Yeast and other fungi