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Peptavlon: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Peptavlon - General Information

A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid. [PubChem]

 

Pharmacology of Peptavlon

Peptavlon is indicated as a diagnostic aid for evaluation of gastric acid secretory function. It is effective in testing for anacidity (achlorhydria) in patients with suspected pernicious anemia, atrophic gastritis, or gastric carcinoma. It is also effective in determining the reduction in acid output after operations for peptic ulcer, such as vagotomy or gastric resection.

 

Additional information about Peptavlon

Peptavlon Indication: Used as a diagnostic aid for evaluation of gastric acid secretory function Mechanism Of Action: The exact mechanism by which pentagastrin stimulates gastric acid, pepsin, and intrinsic factor secretion is unknown; however, since pentagastrin is an analogue of natural gastrin, it is believed that it excites the oxyntic cells of the stomach to secrete to their maximum capacity. Peptavlon stimulates pancreatic secretion, especially when administered in large intramuscular doses. Peptavlon also increases gastrointestinal motility by a direct effect on the intestinal smooth muscle. However, it delays gastric emptying time probably by stimulation of terminal antral contractions, which enhance retropulsion. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Pentagastrin Synonyms: Not Available Drug Category: Diagnostic aid; gastric function Drug Type: Small Molecule; Approved Other Brand Names containing Pentagastrin: Peptavlon; Absorption: Rapidly absorbed after parenteral administration. Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Primarily hepatic Half Life: 10 minutes or less Dosage Forms of Peptavlon: Not Available Chemical IUPAC Name: (3S)-4-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-[[(2S)-2-[[(2S)-3-(1H-indol-3-yl)-2-[3-(2-methylpropoxycarbonylamino)propanoylamino]propanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-oxobutanoic acid Chemical Formula: C37H49N7O9S Pentagastrin on Wikipedia: https://en.wikipedia.org/wiki/Pentagastrin Organisms Affected: Humans and other mammals