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Pentoxyphylline: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Pentoxyphylline - General Information

A methylxanthine derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Pentoxyphylline modulates immunologic activity by stimulating cytokine production. [PubChem]

 

Pharmacology of Pentoxyphylline

Pentoxyphylline, a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine, is used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.

 

Pentoxyphylline for patients

 

Pentoxyphylline Interactions

Although a causal relationship has not been established, there have been reports of bleeding and/or prolonged prothrombin time in patients treated with TRENTAL with and without anticoagulants or platelet aggregation inhibitors. Patients on Warfarin should have more frequent monitoring of prothrombin times, while patients with other risk factors complicated by hemorrhage (e.g., recent surgery, peptic ulceration) should have periodic examinations for bleeding including hematocrit and/or hemoglobin. Concomitant administration of TRENTAL and theophylline-containing drugs leads to increased theophylline levels and theophylline toxicity in some individuals. Such patients should be closely monitored for signs of toxicity and have their theophylline dosage adjusted as necessary. TRENTAL has been used concurrently with antihypertensive drugs, beta blockers, digitalis, diuretics, antidiabetic agents, and antiarrhythmics, without observed problems. Small decreases in blood pressure have been observed in some patients treated with TRENTAL; periodic systemic blood pressure monitoring is recommended for patients receiving concomitant antihypertensive therapy. If indicated, dosage of the antihypertensive agents should be reduced.

 

Pentoxyphylline Contraindications

No information provided.

 

Additional information about Pentoxyphylline

Pentoxyphylline Indication: For the treatment of patients with intermittent lameness or immobility arising from chronic occlusive arterial disease of the limbs. Mechanism Of Action: Pentoxyphylline inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity. Along with erythrocyte activity, pentoxifylline also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity. Drug Interactions: Aminophylline Pentoxyphylline increases the effect and toxicity of theophyllineDyphylline Pentoxyphylline increases the effect and toxicity of theophyllineTheophylline Pentoxyphylline increases the effect and toxicity of theophyllineOxtriphylline Pentoxyphylline increases the effect and toxicity of theophyllineAnisindione Pentoxyphylline increases the anticoagulant effectDicumarol Pentoxyphylline increases the anticoagulant effectAcenocoumarol Pentoxyphylline increases the anticoagulant effectWarfarin Pentoxyphylline increases the anticoagulant effect Food Interactions: Not Available Generic Name: Pentoxifylline Synonyms: Not Available Drug Category: Free Radical Scavengers; Vasodilator Agents; Radiation-Protective Agents; Hematologic Agents; Hemorrheologic Agents Drug Type: Small Molecule; Approved Other Brand Names containing Pentoxifylline: Azupentat; Dimethyloxohexylxanthine; Durapental; Oxpentifylline; PENTOXYPHYLINE; Pentoxifyllin; Pentoxil; Pentoxiphyllium; Pentoxyfylline; Pentoxyphylline; Rentylin; Torental; Trental; Vazofirin; Absorption: Not Available Toxicity (Overdose): LD50=1385 mg/kg(orally in mice) Protein Binding: 70% Biotransformation: Not Available Half Life: 0.4-0.8 hours Dosage Forms of Pentoxyphylline: Tablet, extended release Oral Chemical IUPAC Name: 3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione Chemical Formula: C13H18N4O3 Pentoxifylline on Wikipedia: https://en.wikipedia.org/wiki/Pentoxifylline Organisms Affected: Humans and other mammals