Padil: Full Drug Profile

Padil - General Information

A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. [PubChem]

Pharmacology of Padil

Helps trigger the release of oxygen to the energy requiring cell-making process; Important in the manufacturing of hormones responsible for a strong immune system.

Padil for patients

Glycine supplementation should be avoided by pregnant women and nursing mothers. Because of some conversion of glycine to ammonia, those with hepatic impairment should avoid glycine supplementation unless prescribed. Interactions: Antispastic drugs. Theoretically, supplemental glycine might have additive effects when used in conjunction with baclofen, diazepam, dantrolene sodium and tizanidine.

Padil Interactions

Padil Contraindications

Glycine supplementation is contraindicated in those hypersensitive to any component of the preparation. It is also contraindicated in those who are anuric (some glycine gets converted to ammonia).

Additional information about Padil

Padil Indication

Supplemental glycine may have antispastic activity. Very early findings suggest it may also have antipsychotic activity as well as antioxidant and anti-inflammatory activities.

Mechanism Of Action

In the CNS, there exist strychnine-sensitive glycine binding sites as well as strychnine-insensitive glycine binding sites. The strychnine-insensitive glycine-binding site is located on the NMDA receptor complex. The strychnine-sensitive glycine receptor complex is comprised of a chloride channel and is a member of the ligand-gated ion channel superfamily. The putative antispastic activity of supplemental glycine could be mediated by glycine's binding to strychnine-sensitive binding sites in the spinal cord. This would result in increased chloride conductance and consequent enhancement of inhibitory neurotransmission. The ability of glycine to potentiate NMDA receptor-mediated neurotransmission raised the possibility of its use in the management of neuroleptic-resistant negative symptoms in schizophrenia.

Generic Name

Glycine

Synonyms

2-Aminoacetic acid; Aminoacetic acid; Aminoethanoic acid; Gly

Drug Category

Dietary supplement; Micronutrient; Non-Essential Amino Acids

Drug Type

Small Molecule; Nutraceutical; Approved

Other Brand Names containing Glycine

Aciport; Glicoamin; Glycocoll; Glycolixir; Glycosthene; Gyn-Hydralin; Padil;

Absorption

Absorbed from the small intestine via an active transport mechanism.

Toxicity (Overdose)

ORL-RAT LD₅₀ 7930 mg/kg, SCU-RAT LD₅₀ 5200 mg/kg, IVN-RAT LD₅₀ 2600 mg/kg, ORL-MUS LD₅₀ 4920 mg/kg; Doses of 1 gram daily are very well tolerated. Mild gastrointestinal symptoms are infrequently noted. In one study doses of 90 grams daily were also well tole.

Biotransformation

Hepatic

Dosage Forms of Padil

Liquid Irrigation

Chemical IUPAC Name

2-aminoacetic acid

Chemical Formula

C2H5NO2

Glycine on Wikipedia

https://en.wikipedia.org/wiki/Glycine

Organisms Affected

Humans and other mammals