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OxyFAST: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

OxyFAST - General Information

Semisynthetic derivative of codeine that acts as a narcotic analgesic more potent and addicting than codeine. [PubChem]

 

Pharmacology of OxyFAST

OxyFAST, a semisynthetic opiate agonist derived from the opioid alkaloid, thebaine, is similar to other phenanthrene derivatives such as hydrocodone and morphine. OxyFAST is available in combination with aspirin or acetaminophen to control pain and restless leg and Tourette syndromes.

 

OxyFAST for patients

 

WARNINGS

Drug Dependence: Oxycodone can produce drug dependence of the morphine type, and therefore, has the potential for being abused. Psychic dependence, physical dependence and tolerance may develop upon repeated administration of this drug, and it should be prescribed and administered with the same degree of caution appropriate to the use of other oral narcotic-containing medications. Like other narcotic-containing medications, this drug is subject to the Federal Controlled Substances Act.

Usage in Ambulatory Patients: Oxycodone may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery. The patient using this drug should be cautioned accordingly.

Interaction with Other Central Nervous System Depressants: Patients receiving other narcotic analgesics, general anesthetics, phenothiazines, other tranquilizers, sedative-hypnotics or other CNS depressants (including alcohol) concomitantly with oxycodone hydrochloride may exhibit an additive CNS depression. When such combined therapy is contemplated, the dose of one or both agents should be reduced.

Usage in Pregnancy: Safe use in pregnancy has not been established relative to possible adverse effects on fetal development. Therefore, this drug should not be used in pregnant women unless, in the judgment of the physician, the potential benefits outweigh the possible hazards.

Usage in Children: This drug should not be administered to children.

 

PRECAUTIONS

Head Injury and Increased Intracranial Pressure: The respiratory depressant effects of narcotics and their capacity to elevate cerebrospinal fluid pressure may be markedly exaggerated in the presence of head injury, other intracranial lesions or a pre-existing increase in intracranial pressure. Furthermore, narcotics produce adverse reactions which may obscure the clinical course of patients with head injuries.

Acute Abdominal Conditions: The administration of this drug or other narcotics may obscure the diagnosis or clinical course in patients with acute abdominal conditions.

Special Risk Patients: This drug should be given with caution to certain patients such as the elderly, or debilitated, and those with severe impairment of hepatic or renal function, hypothyroidism, Addison's disease and prostatic hypertrophy or urethral stricture.

 

OxyFAST Interactions

The CNS depressant effects of oxycodone hydrochloride may be additive with that of other CNS depressants..

 

OxyFAST Contraindications

Hypersensitivity to oxycodone.

 

Additional information about OxyFAST

OxyFAST Indication

For the treatment of diarrhoea, pulmonary oedema and for the relief of moderate to moderately severe pain.

Mechanism Of Action
OxyFAST acts as a weak agonist at mu, kappa, and delta opioid receptors within the central nervous system (CNS). OxyFAST primarily affects mu-type opioid receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as oxycodone also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (kappa-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (mu and delta receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
Drug Interactions
Cimetidine Cimetidine increases the effect of the narcotic
Generic Name
Oxycodone
Synonyms
Dihydrohydroxycondeinone; Dihydrohydroxycodeinone; Dihydrone; Oxycodone Hydrochloride; Oxicodona [Inn-Spanish]; Oxycodone Hcl; Oxycodonum [Inn-Latin]
Drug Category
Narcotics; Antitussives; Analgesics, Opioid; Opiate Agonists
Drug Type
Small Molecule; Illicit; Approved
Other Brand Names containing Oxycodone
Combunox; Dihydroxycodeinone; Dinarkon; Diphydrone; Endocet; Endodan; Endone; Eubine; Eucodal; Eucodalum; Eukodal; Eutagen; Oxanest; Oxicon; Oxicone; Oxikon; Oxycodeinone; Oxycodon; Oxycon; Oxycontin; Pancodine; Percobarb; Percodan; Roxicodone; Supendol; Tecodin; Tekodin; Thecodine; Thekodin; OxyIR; OxyNorm; Percolone; OxyFAST; Supeudol;
Absorption
Well absorbed with an oral bioavailability of 60% to 87%
Toxicity (Overdose)
Symptoms of overdose include respiratory depression, somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, bradycardia, hypotension, and death.
Protein Binding
45%
Biotransformation
Hepatic
Half Life
4.5 hours
Dosage Forms of OxyFAST
Tablet, extended release Oral
Chemical IUPAC Name
4, 5-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
Chemical Formula
C18H21NO4
Organisms Affected
Humans and other mammals