Oxilapine
Oxilapine - General Information
An antipsychotic agent used in schizophrenia. [PubChem]
Pharmacology of Oxilapine
Oxilapine, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. Pharmacologically, Oxilapine is a tranquilizer for which the exact mode of action has not been established.
Oxilapine for patients
Patient Information:
Given the likelihood that some patients exposed chronically to neuroleptics
will develop tardive dyskinesia, it is advised that all patients in whom
chronic use is contemplated be given, if possible, full information about
this risk. The decision to inform patients and/or their guardians must
obviously take into account the clinical circumstances and the competency
of the patient to understand the information provided.
Oxilapine Interactions
There have been rare reports of significant respiratory depression, stupor and/or hypotension with the concomitant use of loxapine and lorazepam.
The risk of using loxapine in combination with CNS-Active drugs has not been systematically evaluated. Therefore, caution is advised if the concomitant administration of loxapine and CNS-Active drugs is required.
Oxilapine Contraindications
LOXITANE is contraindicated in comatose or severe drug-induced depressed states (alcohol, barbiturates, narcotics, etc.).
LOXITANE is contraindicated in individuals with known hypersensitivity to dibenzoxazepines.
Additional information about Oxilapine
Oxilapine Indication: For the management of the manifestations of psychotic disorders
Mechanism Of Action: Oxilapine is a dopamine antagonist, and also a serotonin 5-HT2 blocker. The exact mode of action of Oxilapine has not been established, however changes in the level of excitability of subcortical inhibitory areas have been observed in several animal species in association with such manifestations of tranquilization as calming effects and suppression of aggressive behavior.
Drug Interactions: Donepezil Possible antagonism of action
Galantamine Possible antagonism of action
Rivastigmine Possible antagonism of action
Food Interactions: Take with food to reduce irritation. Avoid alcohol.
Generic Name: Loxapine
Synonyms: Not Available
Drug Category: Antipsychotics; Dopamine Antagonists
Drug Type: Small Molecule; Approved
Other Brand Names containing Loxapine: Cloxazepine; Dibenzacepin; Dibenzoazepine; Hydrofluoride 3170; Lossapina [Dcit]; Loxapac; Loxapin; Loxapina [Inn-Spanish]; Loxapine [Usan-Ban-Inn]; Loxapinum [Inn-Latin]; Loxepine; Loxitane C; Loxitane Im; Oxilapine;
Absorption: Systemic bioavailability of the parent drug was only about one third that after an equivalent intramuscular dose (25 mg base) in male volunteers
Toxicity (Overdose): LD50=65 mg/kg (Orally in mice)
Protein Binding: Not Available
Biotransformation: Hepatic
Half Life: Oral-4 hours
Dosage Forms of Oxilapine: Tablet Oral
Solution Oral
Liquid Intramuscular
Chemical IUPAC Name: 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,5]benzoxazepine
Chemical Formula: C18H18ClN3O
Loxapine on Wikipedia: https://en.wikipedia.org/wiki/Loxapine
Organisms Affected: Humans and other mammals
