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Novatrin: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Novatrin - General Information

Homatropine methylbromide is a quaternary ammonium muscarinic acetylcholine receptor antagonist belonging to the group of medicines called anti-muscarinics. Homatropine is used to treat duodenal or stomach ulcers or intestine problems. It can be used together with antacids or other medicine in the treatment of peptic ulcer. It may also be used to prevent nausea, vomiting, and motion sickness.

 

Pharmacology of Novatrin

Homatropine methylbromide belongs to the group of medicines called anti-muscarinics. Homatropine is used to treat duodenal or stomach ulcers or intestine problems. It can be used together with antacids or other medicine in the treatment of peptic ulcer. It may also be used to prevent nausea, vomiting, and motion sickness.

 

Additional information about Novatrin

Novatrin Indication: Used in conjunction with antacids or histamine H2-receptor antagonists in the treatment of peptic ulcers, gastric ulcers and duodenal ulcers, to reduce further gastric acid secretion and delay gastric emptying. Mechanism Of Action: Homatropine is a quaternary ammonium muscarinic acetylcholine receptor antagonist. The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Homatropine methylbromide inhibits the muscarinic actions of acetylcholine on structures innervated by postganglionic cholinergic nerves as well as on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These postganglionic receptor sites are present in the autonomic effector cells of the smooth muscle, cardiac muscle, sinoatrial and atrioventricular nodes, and exocrine glands. Depending on the dose, anticholinergics may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have a slight relaxant action on the bile ducts and gallbladder. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Homatropine Methylbromide Synonyms: Not Available Drug Category: Anti-Ulcer Agents; Antimuscarinics; Antispasmodics Drug Type: Small Molecule; Approved Other Brand Names containing Homatropine Methylbromide: Arkitropin; Camatropine; DL-Homatropine methyl bromide; DL-Methylbromide; Esopin; Homapin; Homatromide; Homatropine methyl bromide; Humulon lead salt; Hycodan, probilagol; Malcotran; Mesopin; Methyl Bromide Homatropine; Methylhomatropine; Methylhomatropine bromide; Novatrin; Novatrine; Novatropine; Npvatropine; Sed-tems; Sethyl; Tropinium methobromide mandelate; Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Novatrin: Not Available Chemical IUPAC Name: (8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate bromide Chemical Formula: C17H24BrNO3 Homatropine Methylbromide on Wikipedia: https://en.wikipedia.org/wiki/Homatropine_Methylbromide Organisms Affected: Humans and other mammals