Nodular
Nodular - General Information
Nodular is a sedative of the piperidinedione derivative family. This medicine was used for treating insomnia, but is now rarely used as it has been replaced by newer drugs with less side effects, such as benzodiazepines. Nodular was withdrawn from the US market in June 1965 and the Canadian market in September 1990. [Wikipedia]
Pharmacology of Nodular
Nodular, a piperidinedione CNS depressant, is close to barbituric acid in structure, but different enough to be called a "non-barbiturate" sedative-hynotic. Nodular is used for insomnia and daytime tension. Nodular depresses the activity of muscle tissues, the heart, and the respiratory system.
Nodular for patients
Nodular Interactions
Methyprylon may interact with other addictive medications, in that it may increase the likelyhood of addiction and abuse. Concurrent use of alcohol and other CNS depression-producing drugs may increase the CNS depressant effects of methyprylon or these other medications.
Nodular Contraindications
Drug abuse or a history of drug abuse, liver impairment (may increase the half-life of methyprylon), intermittent porphyria can be exacerbated, and sensitivity to methyprylon or any of its ingredients.
Additional information about Nodular
Nodular Indication: For the treatment of insomnia.
Mechanism Of Action: Nodular binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Methyprylon
Synonyms: Dea No. 2575; Methyprylon [Inn]; Methyprylone [Inn-French]; Methyprylonum [Inn-Latin]; Methyprolon; Methprylon; Metiprilon; Metiprilona [Inn-Spanish]; Metiprilone
Drug Category: Sedatives and Hypnotics
Drug Type: Small Molecule; Illicit; Approved; Withdrawn
Other Brand Names containing Methyprylon: Dimerin; Noctan; Nodular; Noludar;
Absorption: Not Available
Toxicity (Overdose): Symptoms of overdose include excitation and convulsions.
Protein Binding: 60%
Biotransformation: Hepatic. Methyprylon is almost completely metabolized.
Half Life: 6-16 hours
Dosage Forms of Nodular: Not Available
Chemical IUPAC Name: 3,3-diethyl-5-methylpiperidine-2,4-dione
Chemical Formula: C10H17NO2
Methyprylon on Wikipedia: https://en.wikipedia.org/wiki/Methyprylon
Organisms Affected: Humans and other mammals
