Niaproof-4: Full Drug Profile

Niaproof-4 - General Information

An anionic surface-active agent used for its wetting properties in industry and used in medicine as an irritant and sclerosing agent for hemorrhoids and varicose veins.

Pharmacology of Niaproof-4

Sodium tetradecyl sulfate is an anionic surfactant which occurs as a white, waxy solid. It is used as a sclerosing agent in sclerotherapy. Sclerotherapy is an injection of a sclerosing agent directly through the skin into a lesion and is used primarily for slow-flow vascular anomalies, particularly for venous malformation and lymphatic malformation. Intravenous injection causes intima inflammation and thrombus formation. This usually occludes the injected vein. Subsequent formation of fibrous tissue results in partial or complete vein obliteration that may or may not be permanent.

Niaproof-4 for patients

Niaproof-4 Interactions

Interactions for Sodium Tetradecyl Sulfate:

No well-controlled studies have been performed on patients taking antiovulatory agents. The physician must use judgment and evaluate any patient taking antiovulatory drugs prior to initiating treatment with Sotradecol.

Heparin should not be included in the same syringe as Sodium Tetradecyl Sulfate, since the two are incompatible.

Niaproof-4 Contraindications

Contraindications for Sodium Tetradecyl Sulfate:

Sodium Tetradecyl Sulfate is contraindicated in previous hypersensitivity reactions to the drug; in acute superficial thrombophlebitis; valvular or deep vein incompetence; huge superficial veins with wide open communications to deeper veins; phlebitis migrans; acute cellulitis; allergic conditions; acute infections; varicosities caused by abdominal and pelvic tumors unless the tumor has been removed; bedridden patients; such uncontrolled systemic diseases as diabetes, toxic hyperthyroidism, tuberculosis, asthma, neoplasm, sepsis, blood dyscrasias and acute respiratory or skin diseases.

Additional information about Niaproof-4

Niaproof-4 Indication

For the treatment of small uncomplicated varicose veins of the lower extremities that show simple dilation with competent valves.

Mechanism Of Action

Sodium tetradecyl sulfate is a potent toxin for endothelial cells in that brief exposure to even low concentrations are effective in stripping endothelium over a considerable distance and exposing highly thrombogenic endothelium in the process. Diluted sodium tetradecyl sulfate is also able to induce a hypercoagulable state, possibly by selective inhibition of protein C, and can also promote platelet aggregation.

Generic Name

Sodium Tetradecyl Sulfate

Synonyms

Tetradecyl sulfuric Acid; Tetradecyl sulfate; Tetradecyl sodium sulfate; Tetradecyl hydrogen sulphate; Sodium myristyl sulfate; S.T.D.; STD; Monotetradecylsulfate sodium salt

Drug Category

Surface-Active Agents; Sclerosing Agents

Drug Type

Small Molecule; Approved

Other Brand Names containing Sodium Tetradecyl Sulfate

Niaproof-4; Tergitol-4; Texapon K 14; Sotradecol;

Toxicity (Overdose)

LD₅₀=1250 mg/kg (Orally in rat); LD₅₀=3 ml/kg (Skin in rat)

Dosage Forms of Niaproof-4

Solution Intravenous

Chemical IUPAC Name

sodium tetradecyl sulfate

Chemical Formula

C14H29NaO4S

Organisms Affected

Humans and other mammals