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Neurocil: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Neurocil - General Information

A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)

 

Pharmacology of Neurocil

Neurocil is a phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)

 

Neurocil for patients

 

Neurocil Interactions

Dosages of concomitantly administered opioids should be reduced by approximately half, because levomepromazine amplifies the therapeutic actions and side-effects of opioids. Combination with tramadol (Ultram) is associated with increased risk of seizures.

Additive sedative effects and confusional states may emerge if levomepromazine is given with benzodiazepines or barbiturates. This may be avoided by using the lowest dose possible with the substances in question.

Exert particular caution in combining levomepromazine with other anticholinergic drugs (tricyclic antidepressants and antiparkinsonian-agents): Particularly the elderly may develop delirium, high fever, severe obstipation, even ileus and glaucoma. Reduce both the dose of levomepromazine and the dose of the other drug. If possible, avoid such combinations.

Caffeine and/or stimulantes of the ephedrine/amphetamine type may counteract the specific actions of levomepromazine. Concomitant use of these substances should be avoided.

Coffee and black tea should be avoided because they decrease the absorption of levomepromazine considerably. The same is true for antacids; these should be given 1 to 2 hours before or after oral administration of leveomepromazine.

 

Neurocil Contraindications

 

Additional information about Neurocil

Neurocil Indication: For the treatment of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder. Mechanism Of Action: Neurocil exerts its actions through a central adrenergic-blocking, a dopamine-blocking, a serotonin-blocking, and a anticholinergic blocking. Drug Interactions: Amphetamine Decreased anorexic effect, may increase psychotic symptomsBenzphetamine Decreased anorexic effect, may increase psychotic symptomsDexfenfluramine Decreased anorexic effect, may increase psychotic symptomsDiethylpropion Decreased anorexic effect, may increase psychotic symptomsFenfluramine Decreased anorexic effect, may increase psychotic symptomsMazindol Decreased anorexic effect, may increase psychotic symptomsMethamphetamine Decreased anorexic effect, may increase psychotic symptomsPhendimetrazine Decreased anorexic effect, may increase psychotic symptomsDextroamphetamine Decreased anorexic effect, may increase psychotic symptomsPhenmetrazine Decreased anorexic effect, may increase psychotic symptomsPhentermine Decreased anorexic effect, may increase psychotic symptomsPhenylpropanolamine Decreased anorexic effect, may increase psychotic symptomsTranylcypromine Possible severe adverse reaction with this combinationPhenelzine Possible severe adverse reaction with this combinationIsocarboxazid Possible severe adverse reaction with this combinationPargyline Possible severe adverse reaction with this combinationBromocriptine The phenothiazine decreases the effect of bromocriptineCisapride Increased risk of cardiotoxicity and arrhythmiasGatifloxacin Increased risk of cardiotoxicity and arrhythmiasGrepafloxacin Increased risk of cardiotoxicity and arrhythmiasGuanethidine he agent decreases the effect of guanethidineLevofloxacin Increased risk of cardiotoxicity and arrhythmiasTerfenadine Increased risk of cardiotoxicity and arrhythmiasSparfloxacin Increased risk of cardiotoxicity and arrhythmiasRivastigmine Possible antagonism of actionDonepezil Possible antagonism of actionGalantamine Possible antagonism of actionMetrizamide Increased risk of convulsions Food Interactions: Take with food to reduce irritation. Generic Name: Methotrimeprazine Synonyms: Levomepromazine Drug Category: Antipsychotic Agents; Dopamine Antagonists; Analgesics, Non-Narcotic Drug Type: Small Molecule; Approved Other Brand Names containing Methotrimeprazine: Nosinan; Nozinan; Levoprome; Neurocil; Neozine; Absorption: Methotrimeprazine has an incomplete oral bioavailability, because it undergoes considerable first-pass-metabolism in the liver. Oral bioavailability is approximately 50 to 60%. Toxicity (Overdose): Symptoms of overdose include convulsions, spastic movements, and coma. Protein Binding: Not Available Biotransformation: Hepatic. Methotrimeprazine is metabolized in the liver and degraded to a sulfoxid-, a glucuronid- and a demethyl-moiety. Half Life: Approximately 20 hours. Dosage Forms of Neurocil: Tablet OralSolution Intramuscular Chemical IUPAC Name: (2R)-3-(2-methoxyphenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine Chemical Formula: C19H24N2OS Methotrimeprazine on Wikipedia: https://en.wikipedia.org/wiki/Levomepromazine Organisms Affected: Humans and other mammals