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Neuleptil: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Neuleptil - General Information

Neuleptil is a phenothiazine of the piperidine group. It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. It is a sedative phenothiazine with weak antipsychotic properties. It also has adrenolytic, anticholinergic, metabolic and endocrine effects and an action on the extrapyramidal system. It is used as an adjunctive medication in some psychotic patients, for the control of residual prevailing hostility, impulsiveness and aggressiveness. Pericyazine, like other phenothiazines, is presumed to act principally in the subcortical areas, by producing what has been described as a central adrenergic blockade.

 

Pharmacology of Neuleptil

Pericyazine is a phenothiazine of the piperidine group. It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. It is a sedative phenothiazine with weak antipsychotic properties. It also has adrenolytic, anticholinergic, metabolic and endocrine effects, and an action on the extrapyramidal system.

 

Additional information about Neuleptil

Neuleptil Indication

For use as adjunctive medication in some psychotic patients, for the control of residual prevailing hostility, impulsiveness and aggressiveness.

Mechanism Of Action
Pericyazine, like other phenothiazines, is presumed to act principally in the subcortical areas, by producing what has been described as a central adrenergic blockade.
Drug Interactions
Amphetamine Decreased anorexic effect, may increase pyschotic symptoms
Generic Name
Propericiazine
Synonyms
Pericyazine
Drug Category
Phenothiazines; Antipsychotic Agents
Drug Type
Small Molecule; Approved
Other Brand Names containing Propericiazine
Neuleptil;
Toxicity (Overdose)
In milder cases of phenothiazine overdosage the patient may be agitated, delirious and confused. Frequently he is lethargic or in a comatose state. Twitching, dystonic movements or convulsions may be present and hypotension, cardiovascular collapse, arrhythmias and hypothermia might be observed.
Chemical IUPAC Name
10-[3-(4-hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile
Chemical Formula
C21H23N3OS
Organisms Affected
Humans and other mammals