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Neosporin (Pfizer): Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Neosporin (Pfizer) - General Information

15 residue peptide isolated from Bacillus brevis. With alternating D and L amino acids

 

Pharmacology of Neosporin (Pfizer)

Gramicidin is particularly effective against gram-positive bacteria. Because the drug is highly hemolytic, it cannot be administered internally and so is used only on the skin as a lotion or ointment. It is used primarily in the treatment of infected surface wounds, and in eye, nose, and throat infections. It is normally given with two other antibiotics (neomycin and polymixin B) as an ophthalmic solution

 

Additional information about Neosporin (Pfizer)

Neosporin (Pfizer) Indication: For treatment of skin lesions, surface wounds and eye infections Mechanism Of Action: Neosporin (Pfizer) binds to and inserts itself into bacterial membranes (with a strong preference to gram-positive cell membranes). This results in membrane disruption and permeabilization. This leads to (i) loss of intracellular solutes (e.g., K+ and amino acids); (ii) dissipation of the transmembrane potential; (iii) inhibition of respiration; (iv) a reduction in ATP pools; and (v) inhibition of DNA, RNA, and protein synthesis, which leads to cell death. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Gramicidin D Synonyms: Neosporin Drug Category: Anti-Infectives; Antibiotic Agents; Ophthalmic Antibiotic; Topical Antibiotic Drug Type: Biotech; Approved Other Brand Names containing Gramicidin D: Neosporin (Pfizer); Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Neosporin (Pfizer): Not Available Chemical IUPAC Name: (2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[2-[[(2S)-2-formamido-3-methylbutanoyl]amino]acetyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-(2-hydroxyethylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-4-methylpentanamide Chemical Formula: C99H140N20O17 Gramicidin D on Wikipedia: https://en.wikipedia.org/wiki/Gramicidin_D Organisms Affected: Not Available