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Neositron: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Neositron - General Information

A coumarin that is used as an anticoagulant. Its actions and uses are similar to those of warfarin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p233)

 

Pharmacology of Neositron

Neositron is a coumarin that is used as an anticoagulant. Its actions and uses are similar to those of warfarin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p233)

 

Additional information about Neositron

Neositron Indication: For the treatment and prevention of thromboembolic diseases. Mechanism Of Action: Neositron inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors II, VII, and X) results in decresed prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Acenocoumarol Synonyms: Nitrowarfarin; Nitrovarfarian; Nitrophenylacetylethyl-4-hydroxycoumarine; Acenocoumarolum [inn-latin]; Nicoumalone; Nicumalon; Acenocoumarin Drug Category: Anticoagulants; Coumarin and Indandione Derivatives Drug Type: Small Molecule; Approved Other Brand Names containing Acenocoumarol: Sintrom; Sinthrome; Syncoumar; Syncumar; Syntrom; Zotil; Sinthrom; Sinkumar; Sincoumar; Neositron; Ascumar; Absorption: Not Available Toxicity (Overdose): The onset and severity of the symptoms are dependent on the individual's sensitivity to oral anticoagulants, the severity of the overdosage, and the duration of treatment. Bleeding is the major sign of poisoning with oral anticoagulant drugs. The most frequent symptoms observed are: cutaneous bleeding (80%), haematuria (with renal colic) (52%), haematomas, gastrointestinal bleeding, haematemesis, uterine bleeding, epistaxis, gingival bleeding and bleeding into the joints. Further symptoms include tachycardia, hypotension, peripheral circulatory disorders due to loss of blood, nausea, vomiting, diarrhoea and abdominal pains. Protein Binding: Not Available Biotransformation: Hepatic. Half Life: 8 to 11 hours. Dosage Forms of Neositron: Tablet OralTablet Oral Chemical IUPAC Name: 2-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]chromen-4-one Chemical Formula: C19H15NO6 Acenocoumarol on Wikipedia: https://en.wikipedia.org/wiki/Acenocoumarol Organisms Affected: Humans and other mammals