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Natacyn: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Natacyn - General Information

Amphoteric macrolide antifungal antibiotic from Streptomyces natalensis or S. chattanoogensis. It is used for a variety of fungal infections, mainly topically. [PubChem]

 

Pharmacology of Natacyn

Natacyn is an antifungal drug for topical ophthalmic administration. It is a tetraene polyene antibiotic derived from Streptomyces natalensis. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the activity against fungi is dose-related, natamycin is predominantly fungicidal. Natacyn is not effective in vitro against gram-positive or gram-negative bacteria. Topical administration appears to produce effective concentrations of natamycin within the corneal stroma but not in intraocular fluid.

 

Natacyn for patients

Do not touch dropper tip to any surface, as this may contaminate the suspension.

 

Natacyn Interactions

No Information Provided.

 

Natacyn Contraindications

NATACYN (natamycin ophthalmic suspension, USP) 5% is contraindicated in individuals with a history of hypersensitivity to any of its components.

 

Additional information about Natacyn

Natacyn Indication: For the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani keratitis. Mechanism Of Action: The mechanism of action appears to be through binding of the molecule to the sterol moiety of the fungal cell membrane. The polyenesterol complex alters the permeability of the membrane to produce depletion of essential cellular constituents. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Natamycin Synonyms: Not Available Drug Category: Anti-Bacterial Agents; Anti-Infective Agents, Local; Antifungal Agents Drug Type: Small Molecule; Approved Other Brand Names containing Natamycin: Natacyn; Pimaricin; Absorption: Systemic absorption should not be expected following topical administration, and as with other polyene antibiotics, absorption from the gastrointestinal tract is very poor. Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Natacyn: Suspension / drops Ophthalmic Chemical IUPAC Name: Not Available Chemical Formula: C33H47NO13 Natamycin on Wikipedia: https://en.wikipedia.org/wiki/Natamycin Organisms Affected: Various Fungus Species