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Myocol: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Myocol - General Information

A nucleoside that is composed of adenine and d-ribose. Myocol or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Myocol itself is a neurotransmitter. [PubChem]

 

Pharmacology of Myocol

Myocol is an endogenous nucleoside occurring in all cells of the body and is not chemically related to other antiarrhythmic drugs. Myocol is indicated for the conversion to sinus rhythm of paroxysmal supraventricular tachycardia (PSVT), including that associated with accessory bypass tracts (Wolff-Parkinson-White Syndrome). Myocol is antagonized competitively by methylxanthines such as caffeine and theophylline, and potentiated by blockers of nucleoside transport such as dipyridamole. Myocol is not blocked by atropine.

 

Myocol for patients

 

Myocol Interactions

Intravenous Adenocard (adenosine) has been effectively administered in the presence of other cardioactive drugs, such as quinidine, beta-adrenergic blocking agents, calcium channel blocking agents, and angiotensin converting enzyme inhibitors, without any change in the adverse reaction profile. Digoxin and verapamil use may be rarely associated with ventricular fibrillation when combined with Adenocard. Because of the potential for additive or synergistic depressant effects on the SA and AV nodes, however, Adenocard should be used with caution in the presence of these agents. The use of Adenocard in patients receiving digitalis may be rarely associated with ventricular fibrillation.

The effects of adenosine are antagonized by methylxanthines such as caffeine and theophylline. In the presence of these methylxanthines, larger doses of adenosine may be required or adenosine may not be effective. Adenosine effects are potentiated by dipyridamole. Thus, smaller doses of adenosine may be effective in the presence of dipyridamole. Carbamazepine has been reported to increase the degree of heart block produced by other agents. As the primary effect of adenosine is to decrease conduction through the A-V node, higher degrees of heart block may be produced in the presence of carbamazepine.

 

Myocol Contraindications

Intravenous Adenocard (adenosine) is contraindicated in:

1. Second- or third-degree A-V block (except in patients with a functioning artificial pacemaker).

2. Sinus node disease, such as sick sinus syndrome or symptomatic bradycardia (except in patients with a functioning artificial pacemaker).

3. Known hypersensitivity to adenosine.

 

Additional information about Myocol

Myocol Indication: For controlling paroxysmal supraventricular tachycardia (PSVT). This drug can also be used diagnostically for stable, wide complex tachyardias of unknown type. Mechanism Of Action: Myocol slows conduction time through the A-V node, can interrupt the reentry pathways through the A-V node, and can restore normal sinus rhythm in patients with paroxysmal supraventricular tachycardia (PSVT), including PSVT associated with Wolff-Parkinson-White Syndrome. Drug Interactions: Aminophylline This xanthine decreases the effect of adenosineDipyridamole Dipyridamole increases the effect/toxicity of adenosineDyphylline This xanthine decreases the effect of adenosineTheophylline This xanthine decreases the effect of adenosineDyphylline This xanthine decreases the effect of adenosineOxtriphylline This xanthine decreases the effect of adenosineTheophylline This xanthine decreases the effect of adenosine Food Interactions: Avoid caffeine containing foods and drinks. Generic Name: Adenosine Synonyms: 2'-Deoxyadenosine; Adenine Deoxy Nucleoside; Adenine Deoxyribonucleoside; Adenine Deoxyribose; Adenine Nucleoside; Adenine Riboside; Adenyldeoxyriboside; Deoxyadenosine; Desoxyadenosine; USAF CB-10 Drug Category: Vasodilator Agents; Antiarrhythmic Agents; Analgesics; Cardiac drugs Drug Type: Small Molecule; Approved Other Brand Names containing Adenosine: Adenocard; Adenocor; Adenoscan; Adenosin; Adensoine; Boniton; Myocol; Nucleocardyl; Sandesin; Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Intracellular adenosine is rapidly metabolized either via phosphorylation to adenosine monophosphate by adenosine kinase, or via deamination to inosine by adenosine deaminase in the cytosol. Half Life: Less than 10 secs Dosage Forms of Myocol: Solution IntravenousLiquid Intravenous Chemical IUPAC Name: (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol Chemical Formula: C10H13N5O4 Adenosine on Wikipedia: https://en.wikipedia.org/wiki/Adenosine Organisms Affected: Humans and other mammals