Medical Information Only: This medication is not sold on this site. The information provided is for reference purposes only. Please consult your local physician or pharmacist for treatment.

Moranyl: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Moranyl - General Information

A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties. Moranyl is manufactured by Bayer in Germany as Germanin®.

 

Pharmacology of Moranyl

Not Available

 

Additional information about Moranyl

Moranyl Indication: For treatment of human sleeping sickness, onchocerciasis and other diseases caused by trypanosomes and worms. Mechanism Of Action: The mechanism is unknown, but the trypanocidal activity may be due to the inhibition of enzymes involved with the oxidation of reduced nicotinamide-adenine dinucleotide (NADH), which functions as a co-enzyme in many cellular reactions, such as respiration and glycolysis, in the trypanosome parasite. Moranyl's action in the treatment of onchocerciasis is macrofilaricidal and partially microfilaricidal. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Suramin Synonyms: Bayer 205; SVR; Sodium suramin; Suramin sodium; Suramine; Suramine sodium Drug Category: Antinematodal Agents; Antineoplastic Agents; Trypanocidal Agents Drug Type: Small Molecule; Approved Other Brand Names containing Suramin: Germanin; Antrypol; Fourneau; Farma; Belganyl; Moranyl; Naganil; Naganin; Naganine; Naganol; Naphuride; Absorption: Poorly absorbed from the gastrointestinal tract. Toxicity (Overdose): Not Available Protein Binding: Approximately 99.7% Biotransformation: Little or no metabolism Half Life: Approximately 36 to 60 days Dosage Forms of Moranyl: Injection, powder, for solution Intravenous Chemical IUPAC Name: 8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonic acid Chemical Formula: C51H40N6O23S6 Suramin on Wikipedia: https://en.wikipedia.org/wiki/Suramin Organisms Affected: Yeast, Molds, Trypanosomes