Miostat: Full Drug Profile

Miostat - General Information

A slowly hydrolyzed cholinergic agonist that acts at both muscarinic and nicotinic receptors. [PubChem]

Pharmacology of Miostat

Miostat is a potent cholinergic (parasympathomimetic) agent which produces constriction of the iris and ciliary body resulting in reduction in intraocular pressure. The exact mechanism by which carbachol lowers intraocular pressure is not precisely known. In the cat and rat, carbachol is well-known for its ability to induce rapid eye movement (REM) sleep when microinjected into the pontine reticular formation. Miostat elicits this REM sleep-like state via activation of postsynaptic muscarinic cholinergic receptors (mAChRs).

Miostat for patients

Miostat Interactions

No information provided.

Miostat Contraindications

Should not be used in those persons showing hypersensitivity to any of the components of this preparation.

Additional information about Miostat

Miostat Indication

Primarily used in the treatment of glaucoma, but is also used during ophthalmic surgery.

Mechanism Of Action

Miostat is a parasympathomimetic that stimulates both muscarinic and nicotinic receptors. In topical ocular and intraocular administration its principal effects are miosis and increased aqueous humour outflow.

Generic Name

Carbachol

Drug Category

Analgesics, Non-Narcotic; Cardiotonic Agents; Cholinergic Agonists; Miotics

Drug Type

Small Molecule; Approved

Other Brand Names containing Carbachol

CB; Carbachol USP27; Carbachol chloride; Carbachol hydrochloride; Carbacholin; Carbacholine; Carbacholine chloride; Carbacolina; Carbaminocholine chloride; Carbaminoylcholine chloride; Carbamiotin; Carbamoylcholine chloride; Carbamoylcholine-hydrochloride; Carbamylcholine chloride; Carbastat; Carbastat intraocular; Carbochol; Carbocholin; Carbocholine; Carboptic; Carbyl; Carcholin; Choline carbamate chloride; Choline chloride carbamate; Choline chloride, carbamoyl-; Choline chlorine carbamate; Choline, chloride, carbamate; Coletyl; Doryl; Isopto Carbachol; Jestryl; Karbachol; Karbamoylcholin chlorid; Lentin; Lentine; Miostat; Mistura C; Moryl; P. V. Carbachol; Rilentol; Vasoperif;

Absorption

Not well absorbed in the gastro-intestinal tract, and does not cross the blood-brain barrier.

Toxicity (Overdose)

Oral, mouse: LD₅₀ = 15 mg/kg; Oral, rat: LD₅₀ = 40 mg/kg.

Dosage Forms of Miostat

Liquid Subcutaneous

Chemical IUPAC Name

2-carbamoyloxyethyl-trimethylazanium

Chemical Formula

C6H15N2O2+

Carbachol on Wikipedia

https://en.wikipedia.org/wiki/Carbachol

Organisms Affected

Humans and other mammals