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Minostate: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Minostate - General Information

An imidazole antifungal agent that is used topically and by intravenous infusion. [PubChem]

 

Pharmacology of Minostate

Minostate is an anti-fungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex). It is used either on the skin or in the vagina for fungal infections. Minostate was approved by the FDA in 1974. Minostate prevents fungal organisms from producing vital substances required for growth and function. This medication is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections.

 

Minostate for patients

 

Minostate Interactions

 

Minostate Contraindications

When used by a person taking the anticoagulant medication warfarin, Miconazole may cause an adverse reaction which can lead to excessive bleeding or bruising.

 

Additional information about Minostate

Minostate Indication: For topical application in the treatment of tinea pedis (athlete’s foot), tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, in the treatment of cutaneous candidiasis (moniliasis), and in the treatment of tinea versicolor. Mechanism Of Action: Minostate interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Minostate may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis. Drug Interactions: Warfarin Vaginal miconazole increases the anticoagulant effectAcenocoumarol Vaginal miconazole increases the anticoagulant effectDicumarol Vaginal miconazole increases the anticoagulant effectAnisindione Vaginal miconazole increases the anticoagulant effect Food Interactions: Not Available Generic Name: Miconazole Synonyms: MCZ Drug Category: Antifungal Agents Drug Type: Small Molecule; Approved Other Brand Names containing Miconazole: Daktarin; Femizol-M; M-zole 3 Combination Pack; M-zole 7 Dual Pack; Micatin; Miconazole 3; Miconazole 3 Combination Pack; Miconazole 7; Miconazole 7 Combination Pack; Miconazole Nitrate; Miconazole Nitrate Combination Pack; Miconazole-7; Micozole; Minostate; Monazole 7; Monistat; Monistat 1 Combination Pack; Monistat 3; Monistat 3 Combination Pack; Monistat 3 Dual-Pak; Monistat 3 Vaginal Ovules; Monistat 5; Monistat 5 Tampon; Monistat 7; Monistat 7 Combination Pack; Monistat 7 Dual-Pak; Monistat 7 Vaginal Suppositories; Monistat Dual- PAK; Monistat IV; Monistat-3 Combination Pack; Monistat-Derm; Novo-Miconazole Vaginal Ovules; Absorption: Not Available Toxicity (Overdose): Oral, mouse: LD50 = 3800 mg/kg; Oral, rat: LD50 = 3 gm/kg. Ingestion of the amounts of the components contained in a tube of cream are unlikely to produce overdosage and toxic effects. Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Minostate: Aerosol TopicalCream TopicalSuppository IntravaginalCream Intravaginal Chemical IUPAC Name: 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole Chemical Formula: C18H14Cl4N2O Miconazole on Wikipedia: https://en.wikipedia.org/wiki/Miconazole Organisms Affected: Fungi, yeast and protozoans