Methacin: Full Drug Profile

Methacin - General Information

A quaternary ammonium anticholinergic agent with peripheral side effects similar to those of atropine. It is used as an adjunct in the treatment of gastric and duodenal ulcer, and to relieve visceral spasms. The drug has also been used in the form of eye drops for mydriatic effect. [PubChem]

Pharmacology of Methacin

Methacin is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Methacin is used to treat or prevent spasm in the muscles of the gastrointestinal tract in the irritable bowel syndrome. In addition, Methacin inhibits gastrointestinal propulsive motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions.

Additional information about Methacin

Methacin Indication

For the treatment of visceral spasms

Mechanism Of Action

Action is achieved via a dual mechanism: (1) a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle (musculotropic).

Generic Name

Oxyphenonium

Synonyms

Methocidin [Dcf:Inn]; Methocidine [Inn-French]; Methocidinum [Inn-Latin]; Metocidina [Inn-Spanish]; Oxyphenonium Bromide; Hydroxymethylgramicidin; DCF; Oxiphenonum

Drug Category

Mydriatics; Muscarinic Antagonists; Parasympatholytics

Drug Type

Small Molecule; Approved

Other Brand Names containing Oxyphenonium

Antrenyl; Argicillin; Methacin; Methocidin;

Protein Binding

93% bound to albumin

Chemical IUPAC Name

2-(2-cyclohexyl-2-hydroxy-2-phenylacetyl)oxyethyl-diethyl-methylazanium

Chemical Formula

C21H34NO3+

Organisms Affected

Humans and other mammals