Mephine: Full Drug Profile

Mephine - General Information

A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1248)

Pharmacology of Mephine

Mephine is a sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1248)

Additional information about Mephine

Mephine Indication

Used to maintain blood pressure in hypotensive states.

Mechanism Of Action

Mephine is an alpha adrenergic receptor agonist, but also acts indirectly by releasing endogenous norepinephrine. Cardiac output and systolic and diastolic pressures are usually increased. A change in heart rate is variable, depending on the degree of vagal tone. Sometimes the net vascular effect may be vasodilation. Large doses may depress the myocardium or produce central nervous system (CNS) effects.

Generic Name

Mephentermine

Synonyms

Mephetedrine; Mephenterdrinum; Mephenterdrine; Mefentermin; Mefenterdrin; N-methylphentermine

Drug Category

Adrenergic Agents; Adrenergic alpha-Agonists; Sympathomimetics; Vasoconstrictor Agents

Drug Type

Small Molecule; Approved

Other Brand Names containing Mephentermine

Wyfentermina; Wyamine; Vialin; Mephine;

Biotransformation

Hepatic, by N-demethylation and then p-hydroxylation.

Half Life

17 to 18 hours.

Chemical IUPAC Name

N,2-dimethyl-1-phenylpropan-2-amine

Chemical Formula

C11H17N

Organisms Affected

Humans and other mammals