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Meldian: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Meldian - General Information

A sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. (From Martindale, The Extra Pharmacopoeia, 30th ed, p277)

 

Pharmacology of Meldian

Meldian, a second-generation sulfonylurea antidiabetic agent, is used with diet to lower blood glucose levels in patients with diabetes mellitus type II. Meldian is twice as potent as the related second-generation agent glipizide.

 

Meldian for patients

 

Meldian Interactions

The hypoglycemic action of sulfonylurea may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta adrenergic blocking agents. When such drugs are administered to a patient receiving DIABINESE, the patient should be observed closely for hypoglycemia. When such drugs are withdrawn from a patient receiving DIABINESE, the patient should be observed closely for loss of control.

Certain drugs tend to produce hyperglycemia and may lead to loss of control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. When such drugs are administered to a patient receiving DIABINESE, the patient should be closely observed for loss of control. When such drugs are withdrawn from a patient receiving DIABINESE, the patient should be observed closely for hypoglycemia.

Since animal studies suggest that the action of barbiturates may be prolonged by therapy with chlorpropamide, barbiturates should be employed with caution. In some patients, a disulfiram-like reaction may be produced by the ingestion of alcohol.

A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported. Whether this interaction also occurs with the intravenous, topical, or vaginal preparations of miconazole is not known.

 

Meldian Contraindications

DIABINESE is contraindicated in patients with:

1. Known hypersensitivity to the drug.

2. Diabetic ketoacidosis, with or without coma. This condition should be treated with insulin.

 

Additional information about Meldian

Meldian Indication: For managing hyperglycemia in Non-insulin-dependent diabetes mellitus (NIDDM). Mechanism Of Action: Sulfonylureas such as Meldian likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin. Drug Interactions: Acebutolol The beta-blocker decreases the symptoms of hypoglycemiaAspirin The salicylate increases the effect of sulfonylureaAtenolol The beta-blocker decreases the symptoms of hypoglycemiaBetaxolol The beta-blocker decreases the symptoms of hypoglycemiaBevantolol The beta-blocker decreases the symptoms of hypoglycemiaBismuth The salicylate increases the effect of sulfonylureaBisoprolol The beta-blocker decreases the symptoms of hypoglycemiaCarteolol The beta-blocker decreases the symptoms of hypoglycemiaCarvedilol The beta-blocker decreases the symptoms of hypoglycemiaChloramphenicol The agent increases the effect of sulfonylureaClofibrate The agent increases the effect of sulfonylureaDiazoxide Diazoxyde/sulfonylurea: antagonism of actionDicumarol The agent increase the effect of sulfonylureaEsmolol The beta-blocker decreases the symptoms of hypoglycemiaGlucosamine Possible hyperglycemiaIsocarboxazid The MAO inhibitor increases the effect of hypoglycemic agentLabetalol The beta-blocker decreases the symptoms of hypoglycemiaMetoprolol The beta-blocker decreases the symptoms of hypoglycemiaNadolol The beta-blocker decreases the symptoms of hypoglycemiaPenbutolol The beta-blocker decreases the symptoms of hypoglycemiaPhenelzine The MAO inhibitor increases the effect of hypoglycemic agentPhenylbutazone Phenylbutazone increases the effect of the hypoglycemic agentPindolol The beta-blocker decreases the symptoms of hypoglycemiaPractolol The beta-blocker decreases the symptoms of hypoglycemiaPropranolol The beta-blocker decreases the symptoms of hypoglycemiaRepaglinide Similar mode of action-questionable associationRifampin Rifampin decreases the effect of sulfonylureaSalsalate The salicylate increases the effect of sulfonylureaSotalol The beta-blocker decreases the symptoms of hypoglycemiaSulfacytine Sulfonamide/sulfonylurea: possible hypoglycemiaSulfadiazine Sulfonamide/sulfonylurea: possible hypoglycemiaSulfadoxine Sulfonamide/sulfonylurea: possible hypoglycemiaSulfamethizole Sulfonamide/sulfonylurea: possible hypoglycemiaSulfamethoxazole Sulfonamide/sulfonylurea: possible hypoglycemiaSulfapyridine Sulfonamide/sulfonylurea: possible hypoglycemiaSulfasalazine Sulfonamide/sulfonylurea: possible hypoglycemiaSulfisoxazole Sulfonamide/sulfonylurea: possible hypoglycemiaTimolol The beta-blocker decreases the symptoms of hypoglycemiaTranylcypromine The MAO inhibitor increases the effect of hypoglycemic agentTrisalicylate-choline The salicylate increases the effect of sulfonylureaOxprenolol The beta-blocker decreases the symptoms of hypoglycemiaSulfamerazine Sulfonamide/sulfonylurea: possible hypoglycemiaSulfamethazine Sulfonamide/sulfonylurea: possible hypoglycemia Food Interactions: Take without regard to meals.Avoid alcohol.Food reduces the rate of absorption. Generic Name: Chlorpropamide Synonyms: Not Available Drug Category: Hypoglycemic Agents; Sulfonylureas Drug Type: Small Molecule; Approved Other Brand Names containing Chlorpropamide: Adiaben; Apo-Chlorpropamide; Asucrol; Catanil; Chlorodiabina; Chloronase; Chloropropamide; Chlorpropamid; Chlorpropamide Bp/ Usp; Clorpropamide; Diabaril; Diabechlor; Diabenal; Diabenese; Diabeneza; Diabet-Pages; Diabetoral; Diabinese; Diamel Ex; Dynalase; Glisema; Glucamide; Insulase; Meldian; Melitase; Mellinese; Millinese; Novo-Propamide; Oradian; Stabinol; Absorption: Not Available Toxicity (Overdose): IPN-RAT LD50 580 mg/kg Protein Binding: Not Available Biotransformation: Not Available Half Life: 36 hours Dosage Forms of Meldian: Tablet Oral Chemical IUPAC Name: 1-(4-chlorophenyl)sulfonyl-3-propylurea Chemical Formula: C10H13ClN2O3S Chlorpropamide on Wikipedia: https://en.wikipedia.org/wiki/Chlorpropamide Organisms Affected: Humans and other mammals