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Mazeptil: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Mazeptil - General Information

Mazeptil is a potent neuroleptic with antipsychotic properties. Mazeptil has a marked cataleptic and antiapomorphine activity associated with relatively slight sedative, hypothermic and spasmolytic effects. It is virtually without antiserotonin and hypotensive action and has no antihistaminic property. It is used for the treatment of all types of acute and chronic schizophrenia, including those which did not respond to the usual neuroleptics; manic syndromes.
Overdosage may result in severe extrapyramidal symptoms with dysphagia, marked sialorrhea, persistent and rapidly increasing hyperthermia, pulmonary syndrome, state of shock with pallor and profuse sweating, which may be followed by collapse and coma. LD50 in mice is 70 mg/kg I.V., 120 mg/kg I.P., 500 mg/kg S.C. and 830 mg/kg P.O.

 

Pharmacology of Mazeptil

Mazeptil is a potent neuroleptic with antipsychotic properties. Mazeptil has a marked cataleptic and antiapomorphine activity associated with relatively slight sedative, hypothermic and spasmolytic effects. It is virtually without antiserotonin and hypotensive action and has no antihistaminic property.

 

Additional information about Mazeptil

Mazeptil Indication

For the treatment of all types of acute and chronic schizophrenia, including those which did not respond to the usual neuroleptics; manic syndromes.

Generic Name
Thioproperazine
Synonyms
Tioproferazina [inn-spanish]; Thiproperazine; Thioproperazinum [inn-latin]; Thioproperazin; Thioperazine
Drug Category
Antipsychotic Agents
Drug Type
Small Molecule; Approved
Other Brand Names containing Thioproperazine
Vontil; Sulfenazin; Megeptil; Mazeptyl; Mazeptil; Majeptyl; Cephalmin;
Toxicity (Overdose)
Overdosage may result in severe extrapyramidal symptoms with dysphagia, marked sialorrhea, persistent and rapidly increasing hyperthermia, pulmonary syndrome, state of shock with pallor and profuse sweating, which may be followed by collapse and coma. LD50 in mice is 70 mg/kg I.V., 120 mg/kg I.P., 500 mg/kg S.C. and 830 mg/kg P.O.
Dosage Forms of Mazeptil
Tablet Oral
Chemical IUPAC Name
N,N-dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide
Chemical Formula
C22H30N4O2S2
Organisms Affected
Humans and other mammals